mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic

As an acute respiratory infectious disease, COVID-19 threatens the safety of global public health. Given the current lack of specific treatment against this disease, research and development of vaccines have become sharp weapons for overcoming the pandemic. mRNA vaccines have become the lead in COVI...

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Autores principales: Chen, Peixian, Shi, Xiaoye, He, Weixin, Zhong, Guowei, Tang, Yan, Wang, Hailin, Zhang, Peidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Coronavirus – Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973374/
https://www.ncbi.nlm.nih.gov/pubmed/35321627
http://dx.doi.org/10.1080/21645515.2022.2040330
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author Chen, Peixian
Shi, Xiaoye
He, Weixin
Zhong, Guowei
Tang, Yan
Wang, Hailin
Zhang, Peidong
author_facet Chen, Peixian
Shi, Xiaoye
He, Weixin
Zhong, Guowei
Tang, Yan
Wang, Hailin
Zhang, Peidong
author_sort Chen, Peixian
collection PubMed
description As an acute respiratory infectious disease, COVID-19 threatens the safety of global public health. Given the current lack of specific treatment against this disease, research and development of vaccines have become sharp weapons for overcoming the pandemic. mRNA vaccines have become the lead in COVID-19 vaccination strategies due to their advantages, such as rapid industrial production and efficacy. A total of 137 COVID-19 vaccines have entered the clinical trial stage, among which 23 are mRNA vaccines, accounting for 17% of the total vaccines. Herein, we summarize the research and developmental processes of mRNA vaccines as well as the approach for protecting the human body against infection. Focusing on the latest clinical trial data of two COVID-19 mRNA vaccines from Pfizer and Modena, we discuss their effectiveness and safety. Finally, we analyze the challenges and problems that mRNA vaccines face in controlling the COVID-19 pandemic.
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spelling pubmed-89733742022-04-02 mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic Chen, Peixian Shi, Xiaoye He, Weixin Zhong, Guowei Tang, Yan Wang, Hailin Zhang, Peidong Hum Vaccin Immunother Coronavirus – Review As an acute respiratory infectious disease, COVID-19 threatens the safety of global public health. Given the current lack of specific treatment against this disease, research and development of vaccines have become sharp weapons for overcoming the pandemic. mRNA vaccines have become the lead in COVID-19 vaccination strategies due to their advantages, such as rapid industrial production and efficacy. A total of 137 COVID-19 vaccines have entered the clinical trial stage, among which 23 are mRNA vaccines, accounting for 17% of the total vaccines. Herein, we summarize the research and developmental processes of mRNA vaccines as well as the approach for protecting the human body against infection. Focusing on the latest clinical trial data of two COVID-19 mRNA vaccines from Pfizer and Modena, we discuss their effectiveness and safety. Finally, we analyze the challenges and problems that mRNA vaccines face in controlling the COVID-19 pandemic. Taylor & Francis 2022-03-23 /pmc/articles/PMC8973374/ /pubmed/35321627 http://dx.doi.org/10.1080/21645515.2022.2040330 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Coronavirus – Review
Chen, Peixian
Shi, Xiaoye
He, Weixin
Zhong, Guowei
Tang, Yan
Wang, Hailin
Zhang, Peidong
mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic
title mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic
title_full mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic
title_fullStr mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic
title_full_unstemmed mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic
title_short mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic
title_sort mrna vaccine-a desirable therapeutic strategy for surmounting covid-19 pandemic
topic Coronavirus – Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973374/
https://www.ncbi.nlm.nih.gov/pubmed/35321627
http://dx.doi.org/10.1080/21645515.2022.2040330
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