RAD51 wrestles with SUMO

RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new ro...

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Detalles Bibliográficos
Autores principales: Kee, Younghoon, Lee, Jung-Hee, You, Ho Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973377/
https://www.ncbi.nlm.nih.gov/pubmed/35372672
http://dx.doi.org/10.1080/23723556.2022.2054263
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author Kee, Younghoon
Lee, Jung-Hee
You, Ho Jin
author_facet Kee, Younghoon
Lee, Jung-Hee
You, Ho Jin
author_sort Kee, Younghoon
collection PubMed
description RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.
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spelling pubmed-89733772022-04-02 RAD51 wrestles with SUMO Kee, Younghoon Lee, Jung-Hee You, Ho Jin Mol Cell Oncol Author’s Views RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair. Taylor & Francis 2022-03-31 /pmc/articles/PMC8973377/ /pubmed/35372672 http://dx.doi.org/10.1080/23723556.2022.2054263 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s Views
Kee, Younghoon
Lee, Jung-Hee
You, Ho Jin
RAD51 wrestles with SUMO
title RAD51 wrestles with SUMO
title_full RAD51 wrestles with SUMO
title_fullStr RAD51 wrestles with SUMO
title_full_unstemmed RAD51 wrestles with SUMO
title_short RAD51 wrestles with SUMO
title_sort rad51 wrestles with sumo
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973377/
https://www.ncbi.nlm.nih.gov/pubmed/35372672
http://dx.doi.org/10.1080/23723556.2022.2054263
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