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Mini review: Prospective therapeutic targets of Alzheimer's disease

Alzheimer's disease is a neurological condition that causes the disruption of neuronal connections in the human brain. It is progressive and targets about 10% of the United States population over the age of 65.3 to date, there is no cure to the disease. Physicians can treat symptoms but lack th...

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Autores principales: Mangal, Ruchi, Ding, Yuchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973446/
https://www.ncbi.nlm.nih.gov/pubmed/35372728
http://dx.doi.org/10.4103/bc.bc_20_21
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author Mangal, Ruchi
Ding, Yuchuan
author_facet Mangal, Ruchi
Ding, Yuchuan
author_sort Mangal, Ruchi
collection PubMed
description Alzheimer's disease is a neurological condition that causes the disruption of neuronal connections in the human brain. It is progressive and targets about 10% of the United States population over the age of 65.3 to date, there is no cure to the disease. Physicians can treat symptoms but lack the ability to stop the progression of the disease. However, promising research has come to the surface in recent years. A collection of these therapeutic targets, which have yielded positive results in mice models, are presented in this article. They include targets such as meningeal lymphatics, mitochondrial homeostasis, genomic instability, calcium homeostasis, and cold-shock proteins such as RNA-binding motif protein 3 and reticulon-3, high-density lipoprotein, and antibodies.
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spelling pubmed-89734462022-04-02 Mini review: Prospective therapeutic targets of Alzheimer's disease Mangal, Ruchi Ding, Yuchuan Brain Circ Review Article Alzheimer's disease is a neurological condition that causes the disruption of neuronal connections in the human brain. It is progressive and targets about 10% of the United States population over the age of 65.3 to date, there is no cure to the disease. Physicians can treat symptoms but lack the ability to stop the progression of the disease. However, promising research has come to the surface in recent years. A collection of these therapeutic targets, which have yielded positive results in mice models, are presented in this article. They include targets such as meningeal lymphatics, mitochondrial homeostasis, genomic instability, calcium homeostasis, and cold-shock proteins such as RNA-binding motif protein 3 and reticulon-3, high-density lipoprotein, and antibodies. Wolters Kluwer - Medknow 2022-03-21 /pmc/articles/PMC8973446/ /pubmed/35372728 http://dx.doi.org/10.4103/bc.bc_20_21 Text en Copyright: © 2022 Brain Circulation https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Mangal, Ruchi
Ding, Yuchuan
Mini review: Prospective therapeutic targets of Alzheimer's disease
title Mini review: Prospective therapeutic targets of Alzheimer's disease
title_full Mini review: Prospective therapeutic targets of Alzheimer's disease
title_fullStr Mini review: Prospective therapeutic targets of Alzheimer's disease
title_full_unstemmed Mini review: Prospective therapeutic targets of Alzheimer's disease
title_short Mini review: Prospective therapeutic targets of Alzheimer's disease
title_sort mini review: prospective therapeutic targets of alzheimer's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973446/
https://www.ncbi.nlm.nih.gov/pubmed/35372728
http://dx.doi.org/10.4103/bc.bc_20_21
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