Alternative autophagy: mechanisms and roles in different diseases

As an important mechanism to maintain cellular homeostasis, autophagy exerts critical functions via degrading misfolded proteins and damaged organelles. Recent years, alternative autophagy, a new type of autophagy has been revealed, which shares similar morphology with canonical autophagy but is ind...

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Detalles Bibliográficos
Autores principales: Feng, Hong, Wang, Nian, Zhang, Nan, Liao, Hai-han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973741/
https://www.ncbi.nlm.nih.gov/pubmed/35361231
http://dx.doi.org/10.1186/s12964-022-00851-1
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author Feng, Hong
Wang, Nian
Zhang, Nan
Liao, Hai-han
author_facet Feng, Hong
Wang, Nian
Zhang, Nan
Liao, Hai-han
author_sort Feng, Hong
collection PubMed
description As an important mechanism to maintain cellular homeostasis, autophagy exerts critical functions via degrading misfolded proteins and damaged organelles. Recent years, alternative autophagy, a new type of autophagy has been revealed, which shares similar morphology with canonical autophagy but is independent of Atg5/Atg7. Investigations on different diseases showed the pivotal role of alternative autophagy during their physio-pathological processes, including heart diseases, neurodegenerative diseases, oncogenesis, inflammatory bowel disease (IBD), and bacterial infection. However, the studies are limited and the precise roles and mechanisms of alternative autophagy are far from clear. It is necessary to review current research on alternative autophagy and get some hint in order to provide new insight for further study. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00851-1.
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spelling pubmed-89737412022-04-02 Alternative autophagy: mechanisms and roles in different diseases Feng, Hong Wang, Nian Zhang, Nan Liao, Hai-han Cell Commun Signal Review As an important mechanism to maintain cellular homeostasis, autophagy exerts critical functions via degrading misfolded proteins and damaged organelles. Recent years, alternative autophagy, a new type of autophagy has been revealed, which shares similar morphology with canonical autophagy but is independent of Atg5/Atg7. Investigations on different diseases showed the pivotal role of alternative autophagy during their physio-pathological processes, including heart diseases, neurodegenerative diseases, oncogenesis, inflammatory bowel disease (IBD), and bacterial infection. However, the studies are limited and the precise roles and mechanisms of alternative autophagy are far from clear. It is necessary to review current research on alternative autophagy and get some hint in order to provide new insight for further study. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00851-1. BioMed Central 2022-03-31 /pmc/articles/PMC8973741/ /pubmed/35361231 http://dx.doi.org/10.1186/s12964-022-00851-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Feng, Hong
Wang, Nian
Zhang, Nan
Liao, Hai-han
Alternative autophagy: mechanisms and roles in different diseases
title Alternative autophagy: mechanisms and roles in different diseases
title_full Alternative autophagy: mechanisms and roles in different diseases
title_fullStr Alternative autophagy: mechanisms and roles in different diseases
title_full_unstemmed Alternative autophagy: mechanisms and roles in different diseases
title_short Alternative autophagy: mechanisms and roles in different diseases
title_sort alternative autophagy: mechanisms and roles in different diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973741/
https://www.ncbi.nlm.nih.gov/pubmed/35361231
http://dx.doi.org/10.1186/s12964-022-00851-1
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