Melatonin alleviates lipopolysaccharide (LPS) / adenosine triphosphate (ATP)-induced pyroptosis in rat alveolar Type II cells (RLE-6TN) through nuclear factor erythroid 2-related factor 2 (Nrf2)-driven reactive oxygen species (ROS) downregulation

Pyroptosis has pivotal parts within disease development, rendering this attractive mechanism for novel therapeutics. This investigation aimed at analyzing melatonin roles within pyroptosis together with related mechanistics. RLE-6TN cultures were exposed to varying LPS doses for 4.5 h followed by co...

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Detalles Bibliográficos
Autores principales: Zhou, Tao, Li, Zhaodong, Chen, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973817/
https://www.ncbi.nlm.nih.gov/pubmed/35109747
http://dx.doi.org/10.1080/21655979.2021.2018981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973817/
https://www.ncbi.nlm.nih.gov/pubmed/35109747
http://dx.doi.org/10.1080/21655979.2021.2018981

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