A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

Acute myeloid leukemia with KMT2A (MLL) rearrangements is characterized by specific patterns of gene expression and enhancer architecture, implying unique core transcriptional regulatory circuitry. Here, we identified the transcription factors MEF2D and IRF8 as selective transcriptional dependencies...

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Detalles Bibliográficos
Autores principales: Harada, Taku, Heshmati, Yaser, Kalfon, Jérémie, Perez, Monika W., Xavier Ferrucio, Juliana, Ewers, Jazmin, Hubbell Engler, Benjamin, Kossenkov, Andrew, Ellegast, Jana M., Yi, Joanna S., Bowker, Allyson, Zhu, Qian, Eagle, Kenneth, Liu, Tianxin, Kai, Yan, Dempster, Joshua M., Kugener, Guillaume, Wickramasinghe, Jayamanna, Herbert, Zachary T., Li, Charles H., Vrabič Koren, Jošt, Weinstock, David M., Paralkar, Vikram R., Nabet, Behnam, Lin, Charles Y., Dharia, Neekesh V., Stegmaier, Kimberly, Orkin, Stuart H., Pimkin, Maxim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973843/
https://www.ncbi.nlm.nih.gov/pubmed/35301220
http://dx.doi.org/10.1101/gad.349284.121

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