Chimeric antigen receptors containing the OX40 signalling domain enhance the persistence of T cells even under repeated stimulation with multiple myeloma target cells

Persistence of CAR-T cell function is associated with relapse rate after CAR-T therapy, while co-stimulatory agents are highly concerned with the persistence of CAR-T cells. In this study, we designed and constructed a series of BCMA-targeting second-generation CAR constructs containing CD28, 41BB,...

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Detalles Bibliográficos
Autores principales: Tan, Jingwen, Jia, Yujie, Zhou, Meixia, Fu, Chengcheng, Tuhin, Israth Jahan, Ye, Jing, Monty, Masuma Akter, Xu, Nan, Kang, Liqing, Li, Minghao, Shao, Jiaqi, Fang, Xiaoyan, Zhu, Hongjia, Yan, Lingzhi, Qu, Changju, Xue, Shengli, Jin, Zhengming, Chen, Suning, Huang, Haiwen, Xu, Yang, Chen, Jia, Miao, Miao, Tang, Xiaowen, Li, Caixia, Yan, Zhiqiang, Wu, Depei, Yu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974082/
https://www.ncbi.nlm.nih.gov/pubmed/35365211
http://dx.doi.org/10.1186/s13045-022-01244-0

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