Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential

Pyroptosis is an inflammatory type of regulated cell death that is dependent on inflammasome activation and downstream proteases such as caspase-1 or caspase 4/5/11. The main executors are gasdermins, which have an inherent pore-forming function on the membrane and release inflammatory cytokines, su...

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Detalles Bibliográficos
Autores principales: Liu, Jingjing, Fan, Guoqing, Tao, Ningning, Sun, Tieying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974246/
https://www.ncbi.nlm.nih.gov/pubmed/35370413
http://dx.doi.org/10.2147/JIR.S352563
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author Liu, Jingjing
Fan, Guoqing
Tao, Ningning
Sun, Tieying
author_facet Liu, Jingjing
Fan, Guoqing
Tao, Ningning
Sun, Tieying
author_sort Liu, Jingjing
collection PubMed
description Pyroptosis is an inflammatory type of regulated cell death that is dependent on inflammasome activation and downstream proteases such as caspase-1 or caspase 4/5/11. The main executors are gasdermins, which have an inherent pore-forming function on the membrane and release inflammatory cytokines, such as interleukin (IL)-1β, IL-18 and high mobility group box 1. Emerging evidence demonstrates that pyroptosis is involved in the pathogenesis of various pulmonary diseases. In this review, we mainly discuss the biological mechanisms of pyroptosis, explore the relationship between pyroptosis and respiratory diseases, and discuss emerging therapeutic strategies for respiratory diseases.
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spelling pubmed-89742462022-04-02 Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential Liu, Jingjing Fan, Guoqing Tao, Ningning Sun, Tieying J Inflamm Res Review Pyroptosis is an inflammatory type of regulated cell death that is dependent on inflammasome activation and downstream proteases such as caspase-1 or caspase 4/5/11. The main executors are gasdermins, which have an inherent pore-forming function on the membrane and release inflammatory cytokines, such as interleukin (IL)-1β, IL-18 and high mobility group box 1. Emerging evidence demonstrates that pyroptosis is involved in the pathogenesis of various pulmonary diseases. In this review, we mainly discuss the biological mechanisms of pyroptosis, explore the relationship between pyroptosis and respiratory diseases, and discuss emerging therapeutic strategies for respiratory diseases. Dove 2022-03-28 /pmc/articles/PMC8974246/ /pubmed/35370413 http://dx.doi.org/10.2147/JIR.S352563 Text en © 2022 Liu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Liu, Jingjing
Fan, Guoqing
Tao, Ningning
Sun, Tieying
Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
title Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
title_full Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
title_fullStr Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
title_full_unstemmed Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
title_short Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
title_sort role of pyroptosis in respiratory diseases and its therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974246/
https://www.ncbi.nlm.nih.gov/pubmed/35370413
http://dx.doi.org/10.2147/JIR.S352563
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