R-Loop–Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin

Histone deacetylase inhibitors (HDACi) induce hyperacetylation of histones by blocking HDAC catalytic sites. Despite regulatory approvals in hematological malignancies, limited solid tumor clinical activity has constrained their potential, arguing for better understanding of mechanisms of action (MO...

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Detalles Bibliográficos
Autores principales: Safari, Maryam, Litman, Thomas, Robey, Robert W., Aguilera, Andrés, Chakraborty, Arup R., Reinhold, William C., Basseville, Agnes, Petrukhin, Lubov, Scotto, Luigi, O'Connor, Owen A., Pommier, Yves, Fojo, Antonio T., Bates, Susan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Genome Maintenance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974437/
https://www.ncbi.nlm.nih.gov/pubmed/34050002
http://dx.doi.org/10.1158/1541-7786.MCR-20-0833

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