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Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma
The airway epithelium is the primary site where inhaled and resident microbiota interacts between themselves and the host, potentially playing an important role on allergic asthma development and pathophysiology. With the advent of culture independent molecular techniques and high throughput technol...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974763/ https://www.ncbi.nlm.nih.gov/pubmed/35386933 http://dx.doi.org/10.3389/falgy.2020.617240 |
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author | Tzani-Tzanopoulou, Panagiota Skliros, Dimitrios Megremis, Spyridon Xepapadaki, Paraskevi Andreakos, Evangelos Chanishvili, Nina Flemetakis, Emmanouil Kaltsas, Grigoris Taka, Styliani Lebessi, Evangelia Doudoulakakis, Anastassios Papadopoulos, Nikolaos G. |
author_facet | Tzani-Tzanopoulou, Panagiota Skliros, Dimitrios Megremis, Spyridon Xepapadaki, Paraskevi Andreakos, Evangelos Chanishvili, Nina Flemetakis, Emmanouil Kaltsas, Grigoris Taka, Styliani Lebessi, Evangelia Doudoulakakis, Anastassios Papadopoulos, Nikolaos G. |
author_sort | Tzani-Tzanopoulou, Panagiota |
collection | PubMed |
description | The airway epithelium is the primary site where inhaled and resident microbiota interacts between themselves and the host, potentially playing an important role on allergic asthma development and pathophysiology. With the advent of culture independent molecular techniques and high throughput technologies, the complex composition and diversity of bacterial communities of the airways has been well-documented and the notion of the lungs' sterility definitively rejected. Recent studies indicate that the microbial composition of the asthmatic airways across the spectrum of disease severity, differ significantly compared with healthy individuals. In parallel, a growing body of evidence suggests that bacterial viruses (bacteriophages or simply phages), regulating bacterial populations, are present in almost every niche of the human body and can also interact directly with the eukaryotic cells. The triptych of airway epithelial cells, bacterial symbionts and resident phages should be considered as a functional and interdependent unit with direct implications on the respiratory and overall homeostasis. While the role of epithelial cells in asthma pathophysiology is well-established, the tripartite interactions between epithelial cells, bacteria and phages should be scrutinized, both to better understand asthma as a system disorder and to explore potential interventions. |
format | Online Article Text |
id | pubmed-8974763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89747632022-04-05 Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma Tzani-Tzanopoulou, Panagiota Skliros, Dimitrios Megremis, Spyridon Xepapadaki, Paraskevi Andreakos, Evangelos Chanishvili, Nina Flemetakis, Emmanouil Kaltsas, Grigoris Taka, Styliani Lebessi, Evangelia Doudoulakakis, Anastassios Papadopoulos, Nikolaos G. Front Allergy Allergy The airway epithelium is the primary site where inhaled and resident microbiota interacts between themselves and the host, potentially playing an important role on allergic asthma development and pathophysiology. With the advent of culture independent molecular techniques and high throughput technologies, the complex composition and diversity of bacterial communities of the airways has been well-documented and the notion of the lungs' sterility definitively rejected. Recent studies indicate that the microbial composition of the asthmatic airways across the spectrum of disease severity, differ significantly compared with healthy individuals. In parallel, a growing body of evidence suggests that bacterial viruses (bacteriophages or simply phages), regulating bacterial populations, are present in almost every niche of the human body and can also interact directly with the eukaryotic cells. The triptych of airway epithelial cells, bacterial symbionts and resident phages should be considered as a functional and interdependent unit with direct implications on the respiratory and overall homeostasis. While the role of epithelial cells in asthma pathophysiology is well-established, the tripartite interactions between epithelial cells, bacteria and phages should be scrutinized, both to better understand asthma as a system disorder and to explore potential interventions. Frontiers Media S.A. 2021-01-26 /pmc/articles/PMC8974763/ /pubmed/35386933 http://dx.doi.org/10.3389/falgy.2020.617240 Text en Copyright © 2021 Tzani-Tzanopoulou, Skliros, Megremis, Xepapadaki, Andreakos, Chanishvili, Flemetakis, Kaltsas, Taka, Lebessi, Doudoulakakis and Papadopoulos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Allergy Tzani-Tzanopoulou, Panagiota Skliros, Dimitrios Megremis, Spyridon Xepapadaki, Paraskevi Andreakos, Evangelos Chanishvili, Nina Flemetakis, Emmanouil Kaltsas, Grigoris Taka, Styliani Lebessi, Evangelia Doudoulakakis, Anastassios Papadopoulos, Nikolaos G. Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
title | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
title_full | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
title_fullStr | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
title_full_unstemmed | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
title_short | Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma |
title_sort | interactions of bacteriophages and bacteria at the airway mucosa: new insights into the pathophysiology of asthma |
topic | Allergy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974763/ https://www.ncbi.nlm.nih.gov/pubmed/35386933 http://dx.doi.org/10.3389/falgy.2020.617240 |
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