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Incidence of fractures and clinical profile of patients following up at a Fracture Liaison Service in the city of Curitiba

BACKGROUND: Osteoporotic fractures are common, and their incidence are increasing worldwide. The first fracture doubles the risk of new fractures. Despite that, up to 80% of patients with a fragility fracture are evaluated or treated to reduce the risk of new fractures. AIMS: To evaluate the results...

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Autores principales: Inácio, André Manoel, Marques, Larissa Lauzy Macedo, Borba, Victoria Zeghbi Cochenski, Moreira, Carolina Aguiar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974802/
https://www.ncbi.nlm.nih.gov/pubmed/35364784
http://dx.doi.org/10.1007/s40520-022-02116-w
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author Inácio, André Manoel
Marques, Larissa Lauzy Macedo
Borba, Victoria Zeghbi Cochenski
Moreira, Carolina Aguiar
author_facet Inácio, André Manoel
Marques, Larissa Lauzy Macedo
Borba, Victoria Zeghbi Cochenski
Moreira, Carolina Aguiar
author_sort Inácio, André Manoel
collection PubMed
description BACKGROUND: Osteoporotic fractures are common, and their incidence are increasing worldwide. The first fracture doubles the risk of new fractures. Despite that, up to 80% of patients with a fragility fracture are evaluated or treated to reduce the risk of new fractures. AIMS: To evaluate the results of the operation of the hospital Fracture Liaison Service (FLS) and to analyze the clinical characteristics of the patients attending the service in its first 2 years of operation and to estimate the fracture risk reduction ratio. METHODS: The FLS managed patients older than 50 years who were admitted with a low-energy trauma fracture between January 2017 and April 2018. This management consists in a full medical evaluation, nutritional and physical activity guidance, and specific osteoporosis treatment, if needed. RESULTS: We monitored and treated 135 patients. Forty percent of them had a previous fracture and only 20.3% of them received treatment to prevent new fractures. On Kaplan–Meier analysis, the estimated incidence of new fractures over 24 months was 12.1% (95% CI 7.2–20.8%), indicating that the percentage of patients without new fractures due to bone fragility during treatment was estimated at 87.9% (95% CI 79.2–92.8%). CONCLUSIONS: The evaluation and treatment of patients who sustained a fragility fracture to prevent a secondary fracture is effective in reducing the risk of new fractures in high-risk patients.
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spelling pubmed-89748022022-04-04 Incidence of fractures and clinical profile of patients following up at a Fracture Liaison Service in the city of Curitiba Inácio, André Manoel Marques, Larissa Lauzy Macedo Borba, Victoria Zeghbi Cochenski Moreira, Carolina Aguiar Aging Clin Exp Res Original Article BACKGROUND: Osteoporotic fractures are common, and their incidence are increasing worldwide. The first fracture doubles the risk of new fractures. Despite that, up to 80% of patients with a fragility fracture are evaluated or treated to reduce the risk of new fractures. AIMS: To evaluate the results of the operation of the hospital Fracture Liaison Service (FLS) and to analyze the clinical characteristics of the patients attending the service in its first 2 years of operation and to estimate the fracture risk reduction ratio. METHODS: The FLS managed patients older than 50 years who were admitted with a low-energy trauma fracture between January 2017 and April 2018. This management consists in a full medical evaluation, nutritional and physical activity guidance, and specific osteoporosis treatment, if needed. RESULTS: We monitored and treated 135 patients. Forty percent of them had a previous fracture and only 20.3% of them received treatment to prevent new fractures. On Kaplan–Meier analysis, the estimated incidence of new fractures over 24 months was 12.1% (95% CI 7.2–20.8%), indicating that the percentage of patients without new fractures due to bone fragility during treatment was estimated at 87.9% (95% CI 79.2–92.8%). CONCLUSIONS: The evaluation and treatment of patients who sustained a fragility fracture to prevent a secondary fracture is effective in reducing the risk of new fractures in high-risk patients. Springer International Publishing 2022-04-01 2022 /pmc/articles/PMC8974802/ /pubmed/35364784 http://dx.doi.org/10.1007/s40520-022-02116-w Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Inácio, André Manoel
Marques, Larissa Lauzy Macedo
Borba, Victoria Zeghbi Cochenski
Moreira, Carolina Aguiar
Incidence of fractures and clinical profile of patients following up at a Fracture Liaison Service in the city of Curitiba
title Incidence of fractures and clinical profile of patients following up at a Fracture Liaison Service in the city of Curitiba
title_full Incidence of fractures and clinical profile of patients following up at a Fracture Liaison Service in the city of Curitiba
title_fullStr Incidence of fractures and clinical profile of patients following up at a Fracture Liaison Service in the city of Curitiba
title_full_unstemmed Incidence of fractures and clinical profile of patients following up at a Fracture Liaison Service in the city of Curitiba
title_short Incidence of fractures and clinical profile of patients following up at a Fracture Liaison Service in the city of Curitiba
title_sort incidence of fractures and clinical profile of patients following up at a fracture liaison service in the city of curitiba
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974802/
https://www.ncbi.nlm.nih.gov/pubmed/35364784
http://dx.doi.org/10.1007/s40520-022-02116-w
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