Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception

This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8(+) T cells (CD38(+) and HLA-DR(+)) were compared...

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Detalles Bibliográficos
Autores principales: Lohman-Payne, Barbara, Koster, Jacob, Gabriel, Benjamin, Chilengi, Roma, Forman, Leah S, Heeren, Tim, Duffy, Cassandra R, Herlihy, Julie, Crimaldi, Steven, Gill, Chris, Chavuma, Roy, Mwananyanda, Lawrence, Thea, Donald M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974832/
https://www.ncbi.nlm.nih.gov/pubmed/33780543
http://dx.doi.org/10.1093/infdis/jiab095
Descripción
Sumario:This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8(+) T cells (CD38(+) and HLA-DR(+)) were compared among HIV-uninfected (n = 95), cART experienced HIV-infected (n = 111), and cART-naive HIV-infected (n = 21) pregnant women. Immune activation was highest among HIV-infected/cART-naive women but decreased during pregnancy. Immune activation HIV-infected women who started cART during pregnancy was reduced but not to levels similar to those in HIV-uninfected women. The effects of elevated maternal immune activation in pregnancy on subsequent infant health and immunity remain to be determined.

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