Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception

This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8(+) T cells (CD38(+) and HLA-DR(+)) were compared...

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Autores principales: Lohman-Payne, Barbara, Koster, Jacob, Gabriel, Benjamin, Chilengi, Roma, Forman, Leah S, Heeren, Tim, Duffy, Cassandra R, Herlihy, Julie, Crimaldi, Steven, Gill, Chris, Chavuma, Roy, Mwananyanda, Lawrence, Thea, Donald M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974832/
https://www.ncbi.nlm.nih.gov/pubmed/33780543
http://dx.doi.org/10.1093/infdis/jiab095
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author Lohman-Payne, Barbara
Koster, Jacob
Gabriel, Benjamin
Chilengi, Roma
Forman, Leah S
Heeren, Tim
Duffy, Cassandra R
Herlihy, Julie
Crimaldi, Steven
Gill, Chris
Chavuma, Roy
Mwananyanda, Lawrence
Thea, Donald M
author_facet Lohman-Payne, Barbara
Koster, Jacob
Gabriel, Benjamin
Chilengi, Roma
Forman, Leah S
Heeren, Tim
Duffy, Cassandra R
Herlihy, Julie
Crimaldi, Steven
Gill, Chris
Chavuma, Roy
Mwananyanda, Lawrence
Thea, Donald M
author_sort Lohman-Payne, Barbara
collection PubMed
description This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8(+) T cells (CD38(+) and HLA-DR(+)) were compared among HIV-uninfected (n = 95), cART experienced HIV-infected (n = 111), and cART-naive HIV-infected (n = 21) pregnant women. Immune activation was highest among HIV-infected/cART-naive women but decreased during pregnancy. Immune activation HIV-infected women who started cART during pregnancy was reduced but not to levels similar to those in HIV-uninfected women. The effects of elevated maternal immune activation in pregnancy on subsequent infant health and immunity remain to be determined.
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spelling pubmed-89748322022-04-04 Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception Lohman-Payne, Barbara Koster, Jacob Gabriel, Benjamin Chilengi, Roma Forman, Leah S Heeren, Tim Duffy, Cassandra R Herlihy, Julie Crimaldi, Steven Gill, Chris Chavuma, Roy Mwananyanda, Lawrence Thea, Donald M J Infect Dis Major Articles and Brief Reports This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8(+) T cells (CD38(+) and HLA-DR(+)) were compared among HIV-uninfected (n = 95), cART experienced HIV-infected (n = 111), and cART-naive HIV-infected (n = 21) pregnant women. Immune activation was highest among HIV-infected/cART-naive women but decreased during pregnancy. Immune activation HIV-infected women who started cART during pregnancy was reduced but not to levels similar to those in HIV-uninfected women. The effects of elevated maternal immune activation in pregnancy on subsequent infant health and immunity remain to be determined. Oxford University Press 2021-03-29 /pmc/articles/PMC8974832/ /pubmed/33780543 http://dx.doi.org/10.1093/infdis/jiab095 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Lohman-Payne, Barbara
Koster, Jacob
Gabriel, Benjamin
Chilengi, Roma
Forman, Leah S
Heeren, Tim
Duffy, Cassandra R
Herlihy, Julie
Crimaldi, Steven
Gill, Chris
Chavuma, Roy
Mwananyanda, Lawrence
Thea, Donald M
Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception
title Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception
title_full Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception
title_fullStr Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception
title_full_unstemmed Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception
title_short Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception
title_sort persistent immune activation in human immunodeficiency virus–infected pregnant women starting combination antiretroviral therapy after conception
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974832/
https://www.ncbi.nlm.nih.gov/pubmed/33780543
http://dx.doi.org/10.1093/infdis/jiab095
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