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Association of Myeloid Liver Kinase B1 Depletion With a Reduction in Alveolar Macrophage Numbers and an Impaired Host Defense During Gram-Negative Pneumonia

BACKGROUND: Liver kinase B1 (LKB1) has been studied extensively as a tumor suppressor gene (Stk11) in the context of cancer. We hypothesized that myeloid LKB1 plays a role in innate immunity during pneumonia. METHODS: Mice deficient for LKB1 in myeloid cells (LysM-cre × Stk11(fl/fl)) or neutrophils...

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Detalles Bibliográficos
Autores principales:	Otto, Natasja A, de Vos, Alex F, van Heijst, Jeroen W J, Roelofs, Joris J T H, van der Poll, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974838/ https://www.ncbi.nlm.nih.gov/pubmed/32648919 http://dx.doi.org/10.1093/infdis/jiaa416

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