Inflammation and hematopoietic stem cells aging

Hematopoietic stem cells (HSCs) replenish all lineages of blood cells throughout the lifespan. During aging, the repopulation capacity of HSCs declined, and aged HSCs display a tendency for myeloid differentiation. Several intrinsic and extrinsic factors have been identified to promote HSCs aging. I...

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Detalles Bibliográficos
Autores principales: He, Hanqing, Wang, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974904/
https://www.ncbi.nlm.nih.gov/pubmed/35399205
http://dx.doi.org/10.1097/BS9.0000000000000063
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author He, Hanqing
Wang, Jianwei
author_facet He, Hanqing
Wang, Jianwei
author_sort He, Hanqing
collection PubMed
description Hematopoietic stem cells (HSCs) replenish all lineages of blood cells throughout the lifespan. During aging, the repopulation capacity of HSCs declined, and aged HSCs display a tendency for myeloid differentiation. Several intrinsic and extrinsic factors have been identified to promote HSCs aging. In this review, we focus on the contribution of aging-associated inflammation in provoking HSCs aging and discuss the future research direction of inflammation and HSC aging.
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spelling pubmed-89749042022-04-07 Inflammation and hematopoietic stem cells aging He, Hanqing Wang, Jianwei Blood Sci Review Article Hematopoietic stem cells (HSCs) replenish all lineages of blood cells throughout the lifespan. During aging, the repopulation capacity of HSCs declined, and aged HSCs display a tendency for myeloid differentiation. Several intrinsic and extrinsic factors have been identified to promote HSCs aging. In this review, we focus on the contribution of aging-associated inflammation in provoking HSCs aging and discuss the future research direction of inflammation and HSC aging. Lippincott Williams & Wilkins 2020-11-17 /pmc/articles/PMC8974904/ /pubmed/35399205 http://dx.doi.org/10.1097/BS9.0000000000000063 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Association for Blood Sciences. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Review Article
He, Hanqing
Wang, Jianwei
Inflammation and hematopoietic stem cells aging
title Inflammation and hematopoietic stem cells aging
title_full Inflammation and hematopoietic stem cells aging
title_fullStr Inflammation and hematopoietic stem cells aging
title_full_unstemmed Inflammation and hematopoietic stem cells aging
title_short Inflammation and hematopoietic stem cells aging
title_sort inflammation and hematopoietic stem cells aging
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974904/
https://www.ncbi.nlm.nih.gov/pubmed/35399205
http://dx.doi.org/10.1097/BS9.0000000000000063
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