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The regulators of BCR signaling during B cell activation

B lymphocytes produce antibodies under the stimulation of specific antigens, thereby exerting an immune effect. B cells identify antigens by their surface B cell receptor (BCR), which upon stimulation, directs the cell to activate and differentiate into antibody generating plasma cells. Activation o...

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Autores principales: Wen, Yue, Jing, Yukai, Yang, Lu, Kang, Danqing, Jiang, Panpan, Li, Na, Cheng, Jiali, Li, Jingwen, Li, Xingbo, Peng, Zican, Sun, Xizi, Miller, Heather, Sui, Zhiwei, Gong, Quan, Ren, Boxu, Yin, Wei, Liu, Chaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975005/
https://www.ncbi.nlm.nih.gov/pubmed/35402811
http://dx.doi.org/10.1097/BS9.0000000000000026
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author Wen, Yue
Jing, Yukai
Yang, Lu
Kang, Danqing
Jiang, Panpan
Li, Na
Cheng, Jiali
Li, Jingwen
Li, Xingbo
Peng, Zican
Sun, Xizi
Miller, Heather
Sui, Zhiwei
Gong, Quan
Ren, Boxu
Yin, Wei
Liu, Chaohong
author_facet Wen, Yue
Jing, Yukai
Yang, Lu
Kang, Danqing
Jiang, Panpan
Li, Na
Cheng, Jiali
Li, Jingwen
Li, Xingbo
Peng, Zican
Sun, Xizi
Miller, Heather
Sui, Zhiwei
Gong, Quan
Ren, Boxu
Yin, Wei
Liu, Chaohong
author_sort Wen, Yue
collection PubMed
description B lymphocytes produce antibodies under the stimulation of specific antigens, thereby exerting an immune effect. B cells identify antigens by their surface B cell receptor (BCR), which upon stimulation, directs the cell to activate and differentiate into antibody generating plasma cells. Activation of B cells via their BCRs involves signaling pathways that are tightly controlled by various regulators. In this review, we will discuss three major BCR mediated signaling pathways (the PLC-γ2 pathway, PI3K pathway and MAPK pathway) and related regulators, which were roughly divided into positive, negative and mutual-balanced regulators, and the specific regulators of the specific signaling pathway based on regulatory effects.
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spelling pubmed-89750052022-04-07 The regulators of BCR signaling during B cell activation Wen, Yue Jing, Yukai Yang, Lu Kang, Danqing Jiang, Panpan Li, Na Cheng, Jiali Li, Jingwen Li, Xingbo Peng, Zican Sun, Xizi Miller, Heather Sui, Zhiwei Gong, Quan Ren, Boxu Yin, Wei Liu, Chaohong Blood Sci Reviews B lymphocytes produce antibodies under the stimulation of specific antigens, thereby exerting an immune effect. B cells identify antigens by their surface B cell receptor (BCR), which upon stimulation, directs the cell to activate and differentiate into antibody generating plasma cells. Activation of B cells via their BCRs involves signaling pathways that are tightly controlled by various regulators. In this review, we will discuss three major BCR mediated signaling pathways (the PLC-γ2 pathway, PI3K pathway and MAPK pathway) and related regulators, which were roughly divided into positive, negative and mutual-balanced regulators, and the specific regulators of the specific signaling pathway based on regulatory effects. Wolters Kluwer Health 2019-10-21 /pmc/articles/PMC8975005/ /pubmed/35402811 http://dx.doi.org/10.1097/BS9.0000000000000026 Text en Copyright © 2019 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Association for Blood Sciences. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Reviews
Wen, Yue
Jing, Yukai
Yang, Lu
Kang, Danqing
Jiang, Panpan
Li, Na
Cheng, Jiali
Li, Jingwen
Li, Xingbo
Peng, Zican
Sun, Xizi
Miller, Heather
Sui, Zhiwei
Gong, Quan
Ren, Boxu
Yin, Wei
Liu, Chaohong
The regulators of BCR signaling during B cell activation
title The regulators of BCR signaling during B cell activation
title_full The regulators of BCR signaling during B cell activation
title_fullStr The regulators of BCR signaling during B cell activation
title_full_unstemmed The regulators of BCR signaling during B cell activation
title_short The regulators of BCR signaling during B cell activation
title_sort regulators of bcr signaling during b cell activation
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975005/
https://www.ncbi.nlm.nih.gov/pubmed/35402811
http://dx.doi.org/10.1097/BS9.0000000000000026
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