GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis

GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how GSDME-mediated pyroptosis regulates HSCs remains unknown. Here, we s...

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Detalles Bibliográficos
Autores principales: Yang, Xiuxiu, Cong, Tingting, He, Hanqing, Wang, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975053/
https://www.ncbi.nlm.nih.gov/pubmed/35402833
http://dx.doi.org/10.1097/BS9.0000000000000064
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author Yang, Xiuxiu
Cong, Tingting
He, Hanqing
Wang, Jianwei
author_facet Yang, Xiuxiu
Cong, Tingting
He, Hanqing
Wang, Jianwei
author_sort Yang, Xiuxiu
collection PubMed
description GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how GSDME-mediated pyroptosis regulates HSCs remains unknown. Here, we show that hematopoietic stem and progenitor cells are capable to undergo pyroptosis in response to cisplatin treatment and GSDME is one of the genes mediating such process. Gsdme(−/−) mice revealed no difference in the steady state of blood system while Gsdme(−/−) HSCs exhibited compromised reconstitution capacity due to increased apoptosis. Briefly, this study reveals that GSDME modulates HSC function by coordinating pyroptosis and apoptosis.
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spelling pubmed-89750532022-04-07 GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis Yang, Xiuxiu Cong, Tingting He, Hanqing Wang, Jianwei Blood Sci Research Article GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs). While, how GSDME-mediated pyroptosis regulates HSCs remains unknown. Here, we show that hematopoietic stem and progenitor cells are capable to undergo pyroptosis in response to cisplatin treatment and GSDME is one of the genes mediating such process. Gsdme(−/−) mice revealed no difference in the steady state of blood system while Gsdme(−/−) HSCs exhibited compromised reconstitution capacity due to increased apoptosis. Briefly, this study reveals that GSDME modulates HSC function by coordinating pyroptosis and apoptosis. Lippincott Williams & Wilkins 2020-12-08 /pmc/articles/PMC8975053/ /pubmed/35402833 http://dx.doi.org/10.1097/BS9.0000000000000064 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Association for Blood Sciences. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research Article
Yang, Xiuxiu
Cong, Tingting
He, Hanqing
Wang, Jianwei
GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
title GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
title_full GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
title_fullStr GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
title_full_unstemmed GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
title_short GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
title_sort gsdme maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975053/
https://www.ncbi.nlm.nih.gov/pubmed/35402833
http://dx.doi.org/10.1097/BS9.0000000000000064
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AT wangjianwei gsdmemaintainshematopoieticstemcellsbybalancingpyroptosisandapoptosis

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