Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells

Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells...

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Detalles Bibliográficos
Autores principales: Chen, Zehui, Zheng, Yaxin, Yang, Yaling, Kang, Junnan, You, M. James, Tian, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975096/
https://www.ncbi.nlm.nih.gov/pubmed/35402834
http://dx.doi.org/10.1097/BS9.0000000000000071
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author Chen, Zehui
Zheng, Yaxin
Yang, Yaling
Kang, Junnan
You, M. James
Tian, Chen
author_facet Chen, Zehui
Zheng, Yaxin
Yang, Yaling
Kang, Junnan
You, M. James
Tian, Chen
author_sort Chen, Zehui
collection PubMed
description Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells.
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spelling pubmed-89750962022-04-07 Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells Chen, Zehui Zheng, Yaxin Yang, Yaling Kang, Junnan You, M. James Tian, Chen Blood Sci Review Article Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells. Lippincott Williams & Wilkins 2021-04-28 /pmc/articles/PMC8975096/ /pubmed/35402834 http://dx.doi.org/10.1097/BS9.0000000000000071 Text en Copyright © 2021 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Association for Blood Sciences. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review Article
Chen, Zehui
Zheng, Yaxin
Yang, Yaling
Kang, Junnan
You, M. James
Tian, Chen
Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells
title Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells
title_full Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells
title_fullStr Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells
title_full_unstemmed Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells
title_short Abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells
title_sort abnormal bone marrow microenvironment: the “harbor” of acute lymphoblastic leukemia cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975096/
https://www.ncbi.nlm.nih.gov/pubmed/35402834
http://dx.doi.org/10.1097/BS9.0000000000000071
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