The role of cholesterol metabolism in leukemia

Leukemia is a common hematological malignancy with overall poor prognosis. Novel therapies are needed to improve the outcome of leukemia patients. Cholesterol metabolism reprogramming is a featured alteration in leukemia. Many metabolic-related genes and metabolites are essential to the progress and...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Liang, Zhan, Huien, Jiang, Xinya, Li, Yangqiu, Zeng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975102/
https://www.ncbi.nlm.nih.gov/pubmed/35402792
http://dx.doi.org/10.1097/BS9.0000000000000016
_version_ 1784680332889423872
author Zhao, Liang
Zhan, Huien
Jiang, Xinya
Li, Yangqiu
Zeng, Hui
author_facet Zhao, Liang
Zhan, Huien
Jiang, Xinya
Li, Yangqiu
Zeng, Hui
author_sort Zhao, Liang
collection PubMed
description Leukemia is a common hematological malignancy with overall poor prognosis. Novel therapies are needed to improve the outcome of leukemia patients. Cholesterol metabolism reprogramming is a featured alteration in leukemia. Many metabolic-related genes and metabolites are essential to the progress and drug resistance of leukemia. Exploring potential therapeutical targets related to cholesterol homeostasis is a promising area. This review summarized the functions of cholesterol and its derived intermediate metabolites, and also discussed potential agents targeting this metabolic vulnerability in leukemia.
format Online
Article
Text
id pubmed-8975102
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-89751022022-04-07 The role of cholesterol metabolism in leukemia Zhao, Liang Zhan, Huien Jiang, Xinya Li, Yangqiu Zeng, Hui Blood Sci Review Articles Leukemia is a common hematological malignancy with overall poor prognosis. Novel therapies are needed to improve the outcome of leukemia patients. Cholesterol metabolism reprogramming is a featured alteration in leukemia. Many metabolic-related genes and metabolites are essential to the progress and drug resistance of leukemia. Exploring potential therapeutical targets related to cholesterol homeostasis is a promising area. This review summarized the functions of cholesterol and its derived intermediate metabolites, and also discussed potential agents targeting this metabolic vulnerability in leukemia. Wolters Kluwer Health 2019-09-17 /pmc/articles/PMC8975102/ /pubmed/35402792 http://dx.doi.org/10.1097/BS9.0000000000000016 Text en Copyright © 2019 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Association for Blood Sciences. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an-open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review Articles
Zhao, Liang
Zhan, Huien
Jiang, Xinya
Li, Yangqiu
Zeng, Hui
The role of cholesterol metabolism in leukemia
title The role of cholesterol metabolism in leukemia
title_full The role of cholesterol metabolism in leukemia
title_fullStr The role of cholesterol metabolism in leukemia
title_full_unstemmed The role of cholesterol metabolism in leukemia
title_short The role of cholesterol metabolism in leukemia
title_sort role of cholesterol metabolism in leukemia
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975102/
https://www.ncbi.nlm.nih.gov/pubmed/35402792
http://dx.doi.org/10.1097/BS9.0000000000000016
work_keys_str_mv AT zhaoliang theroleofcholesterolmetabolisminleukemia
AT zhanhuien theroleofcholesterolmetabolisminleukemia
AT jiangxinya theroleofcholesterolmetabolisminleukemia
AT liyangqiu theroleofcholesterolmetabolisminleukemia
AT zenghui theroleofcholesterolmetabolisminleukemia
AT zhaoliang roleofcholesterolmetabolisminleukemia
AT zhanhuien roleofcholesterolmetabolisminleukemia
AT jiangxinya roleofcholesterolmetabolisminleukemia
AT liyangqiu roleofcholesterolmetabolisminleukemia
AT zenghui roleofcholesterolmetabolisminleukemia

Ejemplares similares