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Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers

Electrodiagnosis is routinely integrated into clinical neurophysiology practice for peripheral nerve disease diagnoses, such as neuropathy, demyelinating disorders, nerve entrapment/impingement, plexopathy, or radiculopathy. Measured with conventional surface electrodes, the propagation of periphera...

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Autores principales: Bu, Yifeng, Prince, Jacob, Mojtahed, Hamed, Kimball, Donald, Shah, Vishal, Coleman, Todd, Sarkar, Mahasweta, Rao, Ramesh, Huang, Mingxiong, Schwindt, Peter, Borna, Amir, Lerman, Imanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975546/
https://www.ncbi.nlm.nih.gov/pubmed/35370794
http://dx.doi.org/10.3389/fphys.2022.798376
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author Bu, Yifeng
Prince, Jacob
Mojtahed, Hamed
Kimball, Donald
Shah, Vishal
Coleman, Todd
Sarkar, Mahasweta
Rao, Ramesh
Huang, Mingxiong
Schwindt, Peter
Borna, Amir
Lerman, Imanuel
author_facet Bu, Yifeng
Prince, Jacob
Mojtahed, Hamed
Kimball, Donald
Shah, Vishal
Coleman, Todd
Sarkar, Mahasweta
Rao, Ramesh
Huang, Mingxiong
Schwindt, Peter
Borna, Amir
Lerman, Imanuel
author_sort Bu, Yifeng
collection PubMed
description Electrodiagnosis is routinely integrated into clinical neurophysiology practice for peripheral nerve disease diagnoses, such as neuropathy, demyelinating disorders, nerve entrapment/impingement, plexopathy, or radiculopathy. Measured with conventional surface electrodes, the propagation of peripheral nerve action potentials along a nerve is the result of ionic current flow which, according to Ampere’s Law, generates a small magnetic field that is also detected as an “action current” by magnetometers, such as superconducting quantum interference device (SQUID) Magnetoencephalography (MEG) systems. Optically pumped magnetometers (OPMs) are an emerging class of quantum magnetic sensors with a demonstrated sensitivity at the 1 fT/√Hz level, capable of cortical action current detection. But OPMs were ostensibly constrained to low bandwidth therefore precluding their use in peripheral nerve electrodiagnosis. With careful OPM bandwidth characterization, we hypothesized OPMs may also detect compound action current signatures consistent with both Sensory Nerve Action Potential (SNAP) and the Hoffmann Reflex (H-Reflex). In as much, our work confirms OPMs enabled with expanded bandwidth can detect the magnetic signature of both the SNAP and H-Reflex. Taken together, OPMs now show potential as an emerging electrodiagnostic tool.
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spelling pubmed-89755462022-04-02 Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers Bu, Yifeng Prince, Jacob Mojtahed, Hamed Kimball, Donald Shah, Vishal Coleman, Todd Sarkar, Mahasweta Rao, Ramesh Huang, Mingxiong Schwindt, Peter Borna, Amir Lerman, Imanuel Front Physiol Physiology Electrodiagnosis is routinely integrated into clinical neurophysiology practice for peripheral nerve disease diagnoses, such as neuropathy, demyelinating disorders, nerve entrapment/impingement, plexopathy, or radiculopathy. Measured with conventional surface electrodes, the propagation of peripheral nerve action potentials along a nerve is the result of ionic current flow which, according to Ampere’s Law, generates a small magnetic field that is also detected as an “action current” by magnetometers, such as superconducting quantum interference device (SQUID) Magnetoencephalography (MEG) systems. Optically pumped magnetometers (OPMs) are an emerging class of quantum magnetic sensors with a demonstrated sensitivity at the 1 fT/√Hz level, capable of cortical action current detection. But OPMs were ostensibly constrained to low bandwidth therefore precluding their use in peripheral nerve electrodiagnosis. With careful OPM bandwidth characterization, we hypothesized OPMs may also detect compound action current signatures consistent with both Sensory Nerve Action Potential (SNAP) and the Hoffmann Reflex (H-Reflex). In as much, our work confirms OPMs enabled with expanded bandwidth can detect the magnetic signature of both the SNAP and H-Reflex. Taken together, OPMs now show potential as an emerging electrodiagnostic tool. Frontiers Media S.A. 2022-03-18 /pmc/articles/PMC8975546/ /pubmed/35370794 http://dx.doi.org/10.3389/fphys.2022.798376 Text en Copyright © 2022 Bu, Prince, Mojtahed, Kimball, Shah, Coleman, Sarkar, Rao, Huang, Schwindt, Borna and Lerman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Bu, Yifeng
Prince, Jacob
Mojtahed, Hamed
Kimball, Donald
Shah, Vishal
Coleman, Todd
Sarkar, Mahasweta
Rao, Ramesh
Huang, Mingxiong
Schwindt, Peter
Borna, Amir
Lerman, Imanuel
Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers
title Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers
title_full Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers
title_fullStr Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers
title_full_unstemmed Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers
title_short Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers
title_sort peripheral nerve magnetoneurography with optically pumped magnetometers
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975546/
https://www.ncbi.nlm.nih.gov/pubmed/35370794
http://dx.doi.org/10.3389/fphys.2022.798376
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