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Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers
Electrodiagnosis is routinely integrated into clinical neurophysiology practice for peripheral nerve disease diagnoses, such as neuropathy, demyelinating disorders, nerve entrapment/impingement, plexopathy, or radiculopathy. Measured with conventional surface electrodes, the propagation of periphera...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975546/ https://www.ncbi.nlm.nih.gov/pubmed/35370794 http://dx.doi.org/10.3389/fphys.2022.798376 |
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author | Bu, Yifeng Prince, Jacob Mojtahed, Hamed Kimball, Donald Shah, Vishal Coleman, Todd Sarkar, Mahasweta Rao, Ramesh Huang, Mingxiong Schwindt, Peter Borna, Amir Lerman, Imanuel |
author_facet | Bu, Yifeng Prince, Jacob Mojtahed, Hamed Kimball, Donald Shah, Vishal Coleman, Todd Sarkar, Mahasweta Rao, Ramesh Huang, Mingxiong Schwindt, Peter Borna, Amir Lerman, Imanuel |
author_sort | Bu, Yifeng |
collection | PubMed |
description | Electrodiagnosis is routinely integrated into clinical neurophysiology practice for peripheral nerve disease diagnoses, such as neuropathy, demyelinating disorders, nerve entrapment/impingement, plexopathy, or radiculopathy. Measured with conventional surface electrodes, the propagation of peripheral nerve action potentials along a nerve is the result of ionic current flow which, according to Ampere’s Law, generates a small magnetic field that is also detected as an “action current” by magnetometers, such as superconducting quantum interference device (SQUID) Magnetoencephalography (MEG) systems. Optically pumped magnetometers (OPMs) are an emerging class of quantum magnetic sensors with a demonstrated sensitivity at the 1 fT/√Hz level, capable of cortical action current detection. But OPMs were ostensibly constrained to low bandwidth therefore precluding their use in peripheral nerve electrodiagnosis. With careful OPM bandwidth characterization, we hypothesized OPMs may also detect compound action current signatures consistent with both Sensory Nerve Action Potential (SNAP) and the Hoffmann Reflex (H-Reflex). In as much, our work confirms OPMs enabled with expanded bandwidth can detect the magnetic signature of both the SNAP and H-Reflex. Taken together, OPMs now show potential as an emerging electrodiagnostic tool. |
format | Online Article Text |
id | pubmed-8975546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89755462022-04-02 Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers Bu, Yifeng Prince, Jacob Mojtahed, Hamed Kimball, Donald Shah, Vishal Coleman, Todd Sarkar, Mahasweta Rao, Ramesh Huang, Mingxiong Schwindt, Peter Borna, Amir Lerman, Imanuel Front Physiol Physiology Electrodiagnosis is routinely integrated into clinical neurophysiology practice for peripheral nerve disease diagnoses, such as neuropathy, demyelinating disorders, nerve entrapment/impingement, plexopathy, or radiculopathy. Measured with conventional surface electrodes, the propagation of peripheral nerve action potentials along a nerve is the result of ionic current flow which, according to Ampere’s Law, generates a small magnetic field that is also detected as an “action current” by magnetometers, such as superconducting quantum interference device (SQUID) Magnetoencephalography (MEG) systems. Optically pumped magnetometers (OPMs) are an emerging class of quantum magnetic sensors with a demonstrated sensitivity at the 1 fT/√Hz level, capable of cortical action current detection. But OPMs were ostensibly constrained to low bandwidth therefore precluding their use in peripheral nerve electrodiagnosis. With careful OPM bandwidth characterization, we hypothesized OPMs may also detect compound action current signatures consistent with both Sensory Nerve Action Potential (SNAP) and the Hoffmann Reflex (H-Reflex). In as much, our work confirms OPMs enabled with expanded bandwidth can detect the magnetic signature of both the SNAP and H-Reflex. Taken together, OPMs now show potential as an emerging electrodiagnostic tool. Frontiers Media S.A. 2022-03-18 /pmc/articles/PMC8975546/ /pubmed/35370794 http://dx.doi.org/10.3389/fphys.2022.798376 Text en Copyright © 2022 Bu, Prince, Mojtahed, Kimball, Shah, Coleman, Sarkar, Rao, Huang, Schwindt, Borna and Lerman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Bu, Yifeng Prince, Jacob Mojtahed, Hamed Kimball, Donald Shah, Vishal Coleman, Todd Sarkar, Mahasweta Rao, Ramesh Huang, Mingxiong Schwindt, Peter Borna, Amir Lerman, Imanuel Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers |
title | Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers |
title_full | Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers |
title_fullStr | Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers |
title_full_unstemmed | Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers |
title_short | Peripheral Nerve Magnetoneurography With Optically Pumped Magnetometers |
title_sort | peripheral nerve magnetoneurography with optically pumped magnetometers |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975546/ https://www.ncbi.nlm.nih.gov/pubmed/35370794 http://dx.doi.org/10.3389/fphys.2022.798376 |
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