An Unusual Case of Myelodysplastic Syndrome With Intrahepatic Extramedullary Hematopoiesis Leading to Liver Failure

We present a rare case of a 61-year-old male who arrived at the hospital with fatigue and was found to have pancytopenia. Following further workup, he was diagnosed with myelodysplastic syndrome. His initial bilirubin of 3.1 mg/dL rose to 38.0 mg/dL. After a liver biopsy was obtained, intrahepatic e...

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Detalles Bibliográficos
Autores principales: Ternes, Logan, Giangiacomo, Faye, Nassif, Imad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975614/
https://www.ncbi.nlm.nih.gov/pubmed/35382211
http://dx.doi.org/10.7759/cureus.22733
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author Ternes, Logan
Giangiacomo, Faye
Nassif, Imad
author_facet Ternes, Logan
Giangiacomo, Faye
Nassif, Imad
author_sort Ternes, Logan
collection PubMed
description We present a rare case of a 61-year-old male who arrived at the hospital with fatigue and was found to have pancytopenia. Following further workup, he was diagnosed with myelodysplastic syndrome. His initial bilirubin of 3.1 mg/dL rose to 38.0 mg/dL. After a liver biopsy was obtained, intrahepatic extramedullary hematopoiesis (EMH) was diagnosed and showed the liver to be infiltrated by EMH without malignancy. Within 16 days of his stay, he developed liver failure and passed away. Although intrahepatic EMH is uncommon, EMH resulting in infiltration, liver failure, and then death is exceedingly rare.
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spelling pubmed-89756142022-04-04 An Unusual Case of Myelodysplastic Syndrome With Intrahepatic Extramedullary Hematopoiesis Leading to Liver Failure Ternes, Logan Giangiacomo, Faye Nassif, Imad Cureus Internal Medicine We present a rare case of a 61-year-old male who arrived at the hospital with fatigue and was found to have pancytopenia. Following further workup, he was diagnosed with myelodysplastic syndrome. His initial bilirubin of 3.1 mg/dL rose to 38.0 mg/dL. After a liver biopsy was obtained, intrahepatic extramedullary hematopoiesis (EMH) was diagnosed and showed the liver to be infiltrated by EMH without malignancy. Within 16 days of his stay, he developed liver failure and passed away. Although intrahepatic EMH is uncommon, EMH resulting in infiltration, liver failure, and then death is exceedingly rare. Cureus 2022-03-01 /pmc/articles/PMC8975614/ /pubmed/35382211 http://dx.doi.org/10.7759/cureus.22733 Text en Copyright © 2022, Ternes et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ternes, Logan
Giangiacomo, Faye
Nassif, Imad
An Unusual Case of Myelodysplastic Syndrome With Intrahepatic Extramedullary Hematopoiesis Leading to Liver Failure
title An Unusual Case of Myelodysplastic Syndrome With Intrahepatic Extramedullary Hematopoiesis Leading to Liver Failure
title_full An Unusual Case of Myelodysplastic Syndrome With Intrahepatic Extramedullary Hematopoiesis Leading to Liver Failure
title_fullStr An Unusual Case of Myelodysplastic Syndrome With Intrahepatic Extramedullary Hematopoiesis Leading to Liver Failure
title_full_unstemmed An Unusual Case of Myelodysplastic Syndrome With Intrahepatic Extramedullary Hematopoiesis Leading to Liver Failure
title_short An Unusual Case of Myelodysplastic Syndrome With Intrahepatic Extramedullary Hematopoiesis Leading to Liver Failure
title_sort unusual case of myelodysplastic syndrome with intrahepatic extramedullary hematopoiesis leading to liver failure
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975614/
https://www.ncbi.nlm.nih.gov/pubmed/35382211
http://dx.doi.org/10.7759/cureus.22733
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