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Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal

BACKGROUND: Acetaminophen (APAP) is a worldwide antipyretic as well as an analgesic medication. It has been extensively utilized during the outbreak of coronavirus 2019 (COVID-19). APAP misuse would lead to liver injury. Diacerein (DIA), an anthraquinone derivative, has antioxidant and inflammatory...

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Detalles Bibliográficos
Autores principales:	Mohamed Kamel, Gellan Alaa, Harahsheh, Eman, Hussein, Shaimaa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975726/ https://www.ncbi.nlm.nih.gov/pubmed/35366176 http://dx.doi.org/10.1007/s11033-022-07366-5

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