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Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior
Neural stem/progenitor cells (NSPCs) are found in the adult brain and spinal cord, and endogenous or transplanted NSPCs contribute to repair processes and regulate immune responses in the CNS. However, the molecular mechanisms of NSPC survival and integration as well as their fate determination and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975794/ https://www.ncbi.nlm.nih.gov/pubmed/34302526 http://dx.doi.org/10.1007/s00441-021-03490-z |
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author | Chu, Yu-Hsuan Lin, Jia-di Nath, Suvra Schachtrup, Christian |
author_facet | Chu, Yu-Hsuan Lin, Jia-di Nath, Suvra Schachtrup, Christian |
author_sort | Chu, Yu-Hsuan |
collection | PubMed |
description | Neural stem/progenitor cells (NSPCs) are found in the adult brain and spinal cord, and endogenous or transplanted NSPCs contribute to repair processes and regulate immune responses in the CNS. However, the molecular mechanisms of NSPC survival and integration as well as their fate determination and functionality are still poorly understood. Inhibitor of DNA binding (Id) proteins are increasingly recognized as key determinants of NSPC fate specification. Id proteins act by antagonizing the DNA-binding activity of basic helix-loop-helix (bHLH) transcription factors, and the balance of Id and bHLH proteins determines cell fate decisions in numerous cell types and developmental stages. Id proteins are central in responses to environmental changes, as they occur in CNS injury and disease, and cellular responses in adult NSPCs implicate Id proteins as prime candidates for manipulating stemcell behavior. Here, we outline recent advances in understanding Id protein pleiotropic functions in CNS diseases and propose an integrated view of Id proteins and their promise as potential targets in modifying stemcell behavior to ameliorate CNS disease. |
format | Online Article Text |
id | pubmed-8975794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-89757942022-04-07 Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior Chu, Yu-Hsuan Lin, Jia-di Nath, Suvra Schachtrup, Christian Cell Tissue Res Review Neural stem/progenitor cells (NSPCs) are found in the adult brain and spinal cord, and endogenous or transplanted NSPCs contribute to repair processes and regulate immune responses in the CNS. However, the molecular mechanisms of NSPC survival and integration as well as their fate determination and functionality are still poorly understood. Inhibitor of DNA binding (Id) proteins are increasingly recognized as key determinants of NSPC fate specification. Id proteins act by antagonizing the DNA-binding activity of basic helix-loop-helix (bHLH) transcription factors, and the balance of Id and bHLH proteins determines cell fate decisions in numerous cell types and developmental stages. Id proteins are central in responses to environmental changes, as they occur in CNS injury and disease, and cellular responses in adult NSPCs implicate Id proteins as prime candidates for manipulating stemcell behavior. Here, we outline recent advances in understanding Id protein pleiotropic functions in CNS diseases and propose an integrated view of Id proteins and their promise as potential targets in modifying stemcell behavior to ameliorate CNS disease. Springer Berlin Heidelberg 2021-07-24 2022 /pmc/articles/PMC8975794/ /pubmed/34302526 http://dx.doi.org/10.1007/s00441-021-03490-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Chu, Yu-Hsuan Lin, Jia-di Nath, Suvra Schachtrup, Christian Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior |
title | Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior |
title_full | Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior |
title_fullStr | Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior |
title_full_unstemmed | Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior |
title_short | Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior |
title_sort | id proteins: emerging roles in cns disease and targets for modifying neural stemcell behavior |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975794/ https://www.ncbi.nlm.nih.gov/pubmed/34302526 http://dx.doi.org/10.1007/s00441-021-03490-z |
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