TOX4 facilitates promoter-proximal pausing and C-terminal domain dephosphorylation of RNA polymerase II in human cells

TOX4 is one of the regulatory factors of PP1 phosphatases with poorly understood functions. Here we show that chromatin occupancy pattern of TOX4 resembles that of RNA polymerase II (Pol II), and its loss increases cellular level of C-terminal domain (CTD) phosphorylated Pol II but mainly decreases...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ziling, Wu, Aiwei, Wu, Zhen, Wang, Talang, Pan, Yixuan, Li, Bing, Zhang, Xumin, Yu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975821/
https://www.ncbi.nlm.nih.gov/pubmed/35365735
http://dx.doi.org/10.1038/s42003-022-03214-1

Ejemplares similares

Ejemplares similares