Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically

The cyclic five-membered disulfide 1,2-dithiolane has been widely used in chemical biology and in redox probes. Contradictory reports have described it either as nonspecifically reduced in cells, or else as a highly specific substrate for thioredoxin reductase (TrxR). Here we show that 1,2-dithiolan...

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Detalles Bibliográficos
Autores principales: Felber, Jan G., Poczka, Lena, Scholzen, Karoline C., Zeisel, Lukas, Maier, Martin S., Busker, Sander, Theisen, Ulrike, Brandstädter, Christina, Becker, Katja, Arnér, Elias S. J., Thorn-Seshold, Julia, Thorn-Seshold, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975869/
https://www.ncbi.nlm.nih.gov/pubmed/35365603
http://dx.doi.org/10.1038/s41467-022-29136-4

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