Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors

Regeneration of functional B lymphopoiesis from pluripotent stem cells (PSCs) is challenging, and reliable methods have not been developed. Here, we unveiled the guiding role of three essential factors, Lhx2, Hoxa9, and Runx1, the simultaneous expression of which preferentially drives B lineage fate...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Wu, Bingyan, Weng, Qitong, Hu, Fangxiao, Lin, Yunqing, Xia, Chengxiang, Peng, Huan, Wang, Yao, Liu, Xiaofei, Liu, Lijuan, Xiong, Jiapin, Geng, Yang, Zhao, Yalan, Zhang, Mengyun, Du, Juan, Wang, Jinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975874/
https://www.ncbi.nlm.nih.gov/pubmed/34893754
http://dx.doi.org/10.1038/s41423-021-00805-6

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