BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks

The interaction between tumor suppressor BRCA2 and DSS1 is essential for RAD51 recruitment and repair of DNA double stand breaks (DSBs) by homologous recombination (HR). We have generated mice with a leucine to proline substitution at position 2431 of BRCA2, which disrupts this interaction. Although...

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Detalles Bibliográficos
Autores principales: Mishra, Arun Prakash, Hartford, Suzanne A., Sahu, Sounak, Klarmann, Kimberly, Chittela, Rajani Kant, Biswas, Kajal, Jeon, Albert B., Martin, Betty K., Burkett, Sandra, Southon, Eileen, Reid, Susan, Albaugh, Mary E., Karim, Baktiar, Tessarollo, Lino, Keller, Jonathan R., Sharan, Shyam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975877/
https://www.ncbi.nlm.nih.gov/pubmed/35365640
http://dx.doi.org/10.1038/s41467-022-29409-y

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