Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle

The endoplasmic reticulum (ER) regulates cellular protein and lipid biosynthesis. ER dysfunction leads to protein misfolding and the unfolded protein response (UPR), which limits protein synthesis to prevent cytotoxicity. Chronic ER stress in skeletal muscle is a unifying mechanism linking lipotoxic...

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Detalles Bibliográficos
Autores principales: McNally, Ben D., Ashley, Dean F., Hänschke, Lea, Daou, Hélène N., Watt, Nicole T., Murfitt, Steven A., MacCannell, Amanda D. V., Whitehead, Anna, Bowen, T. Scott, Sanders, Francis W. B., Vacca, Michele, Witte, Klaus K., Davies, Graeme R., Bauer, Reinhard, Griffin, Julian L., Roberts, Lee D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975934/
https://www.ncbi.nlm.nih.gov/pubmed/35365625
http://dx.doi.org/10.1038/s41467-022-29363-9

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