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Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression

Overexpression of histone deacetylases (HDACs) in cancer commonly causes resistance to genotoxic-based therapies. Here, we report on the novel mechanism whereby overexpressed class I HDACs increase the resistance of glioblastoma cells to the S(N)1 methylating agent temozolomide (TMZ). The chemothera...

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Detalles Bibliográficos
Autores principales:	Hanisch, Daniela, Krumm, Andrea, Diehl, Tamara, Stork, Carla M., Dejung, Mario, Butter, Falk, Kim, Ella, Brenner, Walburgis, Fritz, Gerhard, Hofmann, Thomas G., Roos, Wynand P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975953/ https://www.ncbi.nlm.nih.gov/pubmed/35365623 http://dx.doi.org/10.1038/s41419-022-04751-7

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