Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification

The evolutionarily conserved serine/threonine kinase mTORC1 is a central regulator of cell growth and proliferation. mTORC1 is activated on the lysosome surface. However, once mTORC1 is activated, it is unclear whether mTORC1 phosphorylates local lysosomal proteins to regulate specific aspects of ly...

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Detalles Bibliográficos
Autores principales: Zi, Zhenzhen, Zhang, Zhuzhen, Feng, Qiang, Kim, Chiho, Wang, Xu-Dong, Scherer, Philipp E., Gao, Jinming, Levine, Beth, Yu, Yonghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976005/
https://www.ncbi.nlm.nih.gov/pubmed/35365663
http://dx.doi.org/10.1038/s41467-022-29461-8

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