The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes by the mixed lineage kinase domain-like (MLKL) pseudokinase after its activation by the upstream kinases, receptor interacting protein kinase (RIPK)-1 and RIPK3, within a complex known as...

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Detalles Bibliográficos
Autores principales: Jacobsen, Annette V., Pierotti, Catia L., Lowes, Kym N., Au, Amanda E., Zhang, Ying, Etemadi, Nima, Fitzgibbon, Cheree, Kersten, Wilhelmus J. A., Samson, André L., van Delft, Mark F., Huang, David C. S., Sabroux, Hélène Jousset, Lessene, Guillaume, Silke, John, Murphy, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976052/
https://www.ncbi.nlm.nih.gov/pubmed/35365636
http://dx.doi.org/10.1038/s41419-022-04740-w

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