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Long-range structural preformation in yes-associated protein precedes encounter complex formation with TEAD

Yes-associated protein (YAP) is a partly intrinsically disordered protein (IDP) that plays a major role as the downstream element of the Hippo pathway. Although the structures of the complex between TEA domain transcription factors (TEADs) and the TEAD-binding domain of YAP are already well characte...

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Detalles Bibliográficos
Autores principales: Feichtinger, Michael, Beier, Andreas, Migotti, Mario, Schmid, Matthias, Bokhovchuk, Fedir, Chène, Patrick, Konrat, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976148/
https://www.ncbi.nlm.nih.gov/pubmed/35378854
http://dx.doi.org/10.1016/j.isci.2022.104099