Optimizing NK-92 serial killers: gamma irradiation, CD95/Fas-ligation, and NK or LAK attack limit cytotoxic efficacy

BACKGROUND: The NK cell line NK-92 and its genetically modified variants are receiving attention as immunotherapies to treat a range of malignancies. However, since NK-92 cells are themselves tumors, they require irradiation prior to transfer and are potentially susceptible to attack by patients’ im...

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Detalles Bibliográficos
Autores principales: Navarrete-Galvan, Lydia, Guglielmo, Michael, Cruz Amaya, Judith, Smith-Gagen, Julie, Lombardi, Vincent C., Merica, Rebecca, Hudig, Dorothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976335/
https://www.ncbi.nlm.nih.gov/pubmed/35366943
http://dx.doi.org/10.1186/s12967-022-03350-6

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