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Nonuremic Calciphylaxis Precipitated by COVID-19 Infection
Calciphylaxis is a rare dermatologic condition that is primarily associated with end-stage renal disease (ESRD). Nonuremic calciphylaxis has been reported in patients with autoimmune disorders such as systemic lupus erythematosus and other hypercoagulable states such as anti-phospholipid syndrome. N...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976412/ https://www.ncbi.nlm.nih.gov/pubmed/35382212 http://dx.doi.org/10.7759/cureus.22796 |
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author | Shuman, Hannah Obri, Mark S Artz, Christina Fadel, Raef Williams, Jonathan |
author_facet | Shuman, Hannah Obri, Mark S Artz, Christina Fadel, Raef Williams, Jonathan |
author_sort | Shuman, Hannah |
collection | PubMed |
description | Calciphylaxis is a rare dermatologic condition that is primarily associated with end-stage renal disease (ESRD). Nonuremic calciphylaxis has been reported in patients with autoimmune disorders such as systemic lupus erythematosus and other hypercoagulable states such as anti-phospholipid syndrome. New research throughout the COVID-19 pandemic has shown an increased inflammatory and coagulopathic complication of COVID-19. We present a case of a patient with nonuremic calciphylaxis following treatment for severe COVID-19 and no known cause of hypercoagulability. A 40-year-old Caucasian female with a history of recent COVID-19 infection requiring hospitalization, hypertension, alcohol abuse, anxiety, and one prior spontaneous miscarriage presented to the hospital with bilateral lower extremity wounds. The wounds were seen to have necrosis and eschar formation, as well as blackened mottled skin, and were extremely painful to the patient. The initial lesions were on the anterior thighs bilaterally and spread laterally and to the lower back. Initial autoimmune workup was non-specific, and biopsy confirmed calciphylaxis. Calciphylaxis is a known dermatologic disease that has high mortality and morbidity, but it is usually associated with ESRD. Some cases have been reported for autoimmune or hypercoagulable states. The disease presents with non-healing, painful skin ulcers that are at a high risk of infection and have poor healing. The case presented shows biopsy-confirmed calciphylaxis in the absence of known etiologies, and we hypothesize that it is due to COVID-19 or COVID-19 aggravating an underlying but unidentified hypercoagulable condition. |
format | Online Article Text |
id | pubmed-8976412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-89764122022-04-04 Nonuremic Calciphylaxis Precipitated by COVID-19 Infection Shuman, Hannah Obri, Mark S Artz, Christina Fadel, Raef Williams, Jonathan Cureus Internal Medicine Calciphylaxis is a rare dermatologic condition that is primarily associated with end-stage renal disease (ESRD). Nonuremic calciphylaxis has been reported in patients with autoimmune disorders such as systemic lupus erythematosus and other hypercoagulable states such as anti-phospholipid syndrome. New research throughout the COVID-19 pandemic has shown an increased inflammatory and coagulopathic complication of COVID-19. We present a case of a patient with nonuremic calciphylaxis following treatment for severe COVID-19 and no known cause of hypercoagulability. A 40-year-old Caucasian female with a history of recent COVID-19 infection requiring hospitalization, hypertension, alcohol abuse, anxiety, and one prior spontaneous miscarriage presented to the hospital with bilateral lower extremity wounds. The wounds were seen to have necrosis and eschar formation, as well as blackened mottled skin, and were extremely painful to the patient. The initial lesions were on the anterior thighs bilaterally and spread laterally and to the lower back. Initial autoimmune workup was non-specific, and biopsy confirmed calciphylaxis. Calciphylaxis is a known dermatologic disease that has high mortality and morbidity, but it is usually associated with ESRD. Some cases have been reported for autoimmune or hypercoagulable states. The disease presents with non-healing, painful skin ulcers that are at a high risk of infection and have poor healing. The case presented shows biopsy-confirmed calciphylaxis in the absence of known etiologies, and we hypothesize that it is due to COVID-19 or COVID-19 aggravating an underlying but unidentified hypercoagulable condition. Cureus 2022-03-03 /pmc/articles/PMC8976412/ /pubmed/35382212 http://dx.doi.org/10.7759/cureus.22796 Text en Copyright © 2022, Shuman et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Shuman, Hannah Obri, Mark S Artz, Christina Fadel, Raef Williams, Jonathan Nonuremic Calciphylaxis Precipitated by COVID-19 Infection |
title | Nonuremic Calciphylaxis Precipitated by COVID-19 Infection |
title_full | Nonuremic Calciphylaxis Precipitated by COVID-19 Infection |
title_fullStr | Nonuremic Calciphylaxis Precipitated by COVID-19 Infection |
title_full_unstemmed | Nonuremic Calciphylaxis Precipitated by COVID-19 Infection |
title_short | Nonuremic Calciphylaxis Precipitated by COVID-19 Infection |
title_sort | nonuremic calciphylaxis precipitated by covid-19 infection |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976412/ https://www.ncbi.nlm.nih.gov/pubmed/35382212 http://dx.doi.org/10.7759/cureus.22796 |
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