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Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Colorectal Carcinoma: A Potential Area of Focus for Future Diagnostics
Objective In this study, we aimed to explore the potential diagnostic utility of human epidermal growth factor receptor 2 (HER2) expression in colorectal carcinoma. We investigated the association of HER2 expression with the type and grade of the tumor along with the pattern, staining intensity, and...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976506/ https://www.ncbi.nlm.nih.gov/pubmed/35382213 http://dx.doi.org/10.7759/cureus.22811 |
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author | Kaur, Simrandeep Gill, Karamjit S Manjari, Mridu Kumar, Surinder Nauhria, Shreya Nath, Reetuparna Patel, Chandni Hamdan, Kamal Jeong, Yujin Nayak, Narendra P Maity, Sabyasachi Hilgers, Rob Nauhria, Samal |
author_facet | Kaur, Simrandeep Gill, Karamjit S Manjari, Mridu Kumar, Surinder Nauhria, Shreya Nath, Reetuparna Patel, Chandni Hamdan, Kamal Jeong, Yujin Nayak, Narendra P Maity, Sabyasachi Hilgers, Rob Nauhria, Samal |
author_sort | Kaur, Simrandeep |
collection | PubMed |
description | Objective In this study, we aimed to explore the potential diagnostic utility of human epidermal growth factor receptor 2 (HER2) expression in colorectal carcinoma. We investigated the association of HER2 expression with the type and grade of the tumor along with the pattern, staining intensity, and the percentage of cells stained. Methods This was an observational study involving 50 cases of colorectal carcinoma that underwent immunohistochemistry to analyze the HER2 expression. Results The positive expression of HER2 was seen in 16 (32%) cases. The majority of the study population was between the fifth-seventh decades of life. The most commonly diagnosed tumor was conventional adenocarcinoma with grade II, cytoplasmic pattern, +2 positivity, and moderate intensity. The maximum positivity for HER2 was seen in tumors of the rectum in eight (16%) cases. Conclusion A substantial rate of HER2 overexpression paves the way for it to become a potential future target in cancer therapeutics. |
format | Online Article Text |
id | pubmed-8976506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-89765062022-04-04 Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Colorectal Carcinoma: A Potential Area of Focus for Future Diagnostics Kaur, Simrandeep Gill, Karamjit S Manjari, Mridu Kumar, Surinder Nauhria, Shreya Nath, Reetuparna Patel, Chandni Hamdan, Kamal Jeong, Yujin Nayak, Narendra P Maity, Sabyasachi Hilgers, Rob Nauhria, Samal Cureus Pathology Objective In this study, we aimed to explore the potential diagnostic utility of human epidermal growth factor receptor 2 (HER2) expression in colorectal carcinoma. We investigated the association of HER2 expression with the type and grade of the tumor along with the pattern, staining intensity, and the percentage of cells stained. Methods This was an observational study involving 50 cases of colorectal carcinoma that underwent immunohistochemistry to analyze the HER2 expression. Results The positive expression of HER2 was seen in 16 (32%) cases. The majority of the study population was between the fifth-seventh decades of life. The most commonly diagnosed tumor was conventional adenocarcinoma with grade II, cytoplasmic pattern, +2 positivity, and moderate intensity. The maximum positivity for HER2 was seen in tumors of the rectum in eight (16%) cases. Conclusion A substantial rate of HER2 overexpression paves the way for it to become a potential future target in cancer therapeutics. Cureus 2022-03-03 /pmc/articles/PMC8976506/ /pubmed/35382213 http://dx.doi.org/10.7759/cureus.22811 Text en Copyright © 2022, Kaur et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pathology Kaur, Simrandeep Gill, Karamjit S Manjari, Mridu Kumar, Surinder Nauhria, Shreya Nath, Reetuparna Patel, Chandni Hamdan, Kamal Jeong, Yujin Nayak, Narendra P Maity, Sabyasachi Hilgers, Rob Nauhria, Samal Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Colorectal Carcinoma: A Potential Area of Focus for Future Diagnostics |
title | Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Colorectal Carcinoma: A Potential Area of Focus for Future Diagnostics |
title_full | Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Colorectal Carcinoma: A Potential Area of Focus for Future Diagnostics |
title_fullStr | Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Colorectal Carcinoma: A Potential Area of Focus for Future Diagnostics |
title_full_unstemmed | Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Colorectal Carcinoma: A Potential Area of Focus for Future Diagnostics |
title_short | Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Colorectal Carcinoma: A Potential Area of Focus for Future Diagnostics |
title_sort | human epidermal growth factor receptor 2 (her2) expression in colorectal carcinoma: a potential area of focus for future diagnostics |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976506/ https://www.ncbi.nlm.nih.gov/pubmed/35382213 http://dx.doi.org/10.7759/cureus.22811 |
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