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Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea
High-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analysis revealed that there are 20 main components in spores and mycelia extract of Cordyceps fumosorosea strain RCEF 6672 including mannitol (1), uridine (2), adenine (3). N(6)-(2-hydroxyethyl)-adenosine (4). N(6)-(2-hyd...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976864/ https://www.ncbi.nlm.nih.gov/pubmed/35366116 http://dx.doi.org/10.1186/s13568-022-01379-w |
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author | Wei, Jie Zhou, Xue Dong, Mei Yang, Lufan Zhao, Cheng Lu, Ruili Bao, Guanhu Hu, Fenglin |
author_facet | Wei, Jie Zhou, Xue Dong, Mei Yang, Lufan Zhao, Cheng Lu, Ruili Bao, Guanhu Hu, Fenglin |
author_sort | Wei, Jie |
collection | PubMed |
description | High-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analysis revealed that there are 20 main components in spores and mycelia extract of Cordyceps fumosorosea strain RCEF 6672 including mannitol (1), uridine (2), adenine (3). N(6)-(2-hydroxyethyl)-adenosine (4). N(6)-(2-hydroxyethylacetate)-adenosine (5), fumosoroseanoside A (6) and B (7), ovalicin-4α-alcohol (8), 1-linoleoyl-sn-glycero-3-phosphocholine (9) and its isomer (10), fumosoroseain A (11) and its isomer (12), 5 non-ribosomal peptides (13 to 17) and 3 fatty acids (18 to 20). The compounds 5, 6, 7, 9 and 11 were prepared with preparative and semi-preparative HPLC and identified with 1D and 2D NMR. Compounds 4 and 5 were the first time identified from C. fumosorosea. Compounds 6, 7 and 11 are novel compounds. Compounds 6 and 7 showed antibacterial and antifungal activities, and 11 showed antiaging activity. All the secondary metabolites (4 to 8 and 11 to 17) have strong bioactivities indicating that the metabolites have pharmaceutical development potentiality. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13568-022-01379-w. |
format | Online Article Text |
id | pubmed-8976864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-89768642022-04-20 Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea Wei, Jie Zhou, Xue Dong, Mei Yang, Lufan Zhao, Cheng Lu, Ruili Bao, Guanhu Hu, Fenglin AMB Express Original Article High-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analysis revealed that there are 20 main components in spores and mycelia extract of Cordyceps fumosorosea strain RCEF 6672 including mannitol (1), uridine (2), adenine (3). N(6)-(2-hydroxyethyl)-adenosine (4). N(6)-(2-hydroxyethylacetate)-adenosine (5), fumosoroseanoside A (6) and B (7), ovalicin-4α-alcohol (8), 1-linoleoyl-sn-glycero-3-phosphocholine (9) and its isomer (10), fumosoroseain A (11) and its isomer (12), 5 non-ribosomal peptides (13 to 17) and 3 fatty acids (18 to 20). The compounds 5, 6, 7, 9 and 11 were prepared with preparative and semi-preparative HPLC and identified with 1D and 2D NMR. Compounds 4 and 5 were the first time identified from C. fumosorosea. Compounds 6, 7 and 11 are novel compounds. Compounds 6 and 7 showed antibacterial and antifungal activities, and 11 showed antiaging activity. All the secondary metabolites (4 to 8 and 11 to 17) have strong bioactivities indicating that the metabolites have pharmaceutical development potentiality. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13568-022-01379-w. Springer Berlin Heidelberg 2022-04-02 /pmc/articles/PMC8976864/ /pubmed/35366116 http://dx.doi.org/10.1186/s13568-022-01379-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Wei, Jie Zhou, Xue Dong, Mei Yang, Lufan Zhao, Cheng Lu, Ruili Bao, Guanhu Hu, Fenglin Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea |
title | Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea |
title_full | Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea |
title_fullStr | Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea |
title_full_unstemmed | Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea |
title_short | Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea |
title_sort | metabolites and novel compounds with anti-microbial or antiaging activities from cordyceps fumosorosea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976864/ https://www.ncbi.nlm.nih.gov/pubmed/35366116 http://dx.doi.org/10.1186/s13568-022-01379-w |
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