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Antimetabolite Drugs Exhibit Distinctive Immunomodulatory Mechanisms and Effects on the Intestinal Microbiota in Experimental Autoimmune Uveitis

PURPOSE: The purpose of this study was to investigate the effect of antimetabolite drugs on T-cell responses and intestinal microbial composition in autoimmune uveitis. METHODS: Experimental autoimmune uveitis (EAU) was induced in C57BL/6J mice treated with 0.00625 mg/mL methotrexate (MTX) or 0.625 ...

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Detalles Bibliográficos
Autores principales:	Llorenç, Victor, Nakamura, Yukiko, Metea, Christina, Karstens, Lisa, Molins, Blanca, Lin, Phoebe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Immunology and Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976920/ https://www.ncbi.nlm.nih.gov/pubmed/35357394 http://dx.doi.org/10.1167/iovs.63.3.30

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