A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma

BACKGROUND: Pancreatic adenocarcinoma (PAAD) is a severe malignant with a 5-year survival rate of approximately 9%. Oleanolic acid is a well-known natural triterpenoid which exhibits pharmacological activities. We previously synthesized a series of oleanolic acid derivatives and evaluated the tumor-...

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Detalles Bibliográficos
Autores principales: Wu, Shijia, Ai, Yong, Huang, Huimin, Wu, Guangyu, Zhou, Shipeng, Hong, Weilong, Akuetteh, Percy David Papa, Jin, Guihua, Zhao, Xingling, Zhang, Yihua, Zhang, Xiaolong, Lan, Linhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976991/
https://www.ncbi.nlm.nih.gov/pubmed/35366902
http://dx.doi.org/10.1186/s12935-022-02562-6

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