Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation

BACKGROUND: The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is often associated with neuroblast stem-ness. Moreover, ASCL1-mediated reprogramming of fi...

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Detalles Bibliográficos
Autores principales: Woods, Laura M., Ali, Fahad R., Gomez, Roshna, Chernukhin, Igor, Marcos, Daniel, Parkinson, Lydia M., Tayoun, Ahmad N. Abou, Carroll, Jason S., Philpott, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977041/
https://www.ncbi.nlm.nih.gov/pubmed/35366798
http://dx.doi.org/10.1186/s12864-022-08495-8

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