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Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study

The aim of this study was to investigate the patient characteristics and laboratory parameters for coronavirus disease-2019 (COVID-19) non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died of COVID-19 in our intens...

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Autores principales: Alici, Gokhan, Barman, Hasan Ali, Asoglu, Ramazan, Atici, Adem, Akciger, Atike Nazli, Sit, Omer, Dogan, Omer, Yavuz, Yucel, Borahan, Songul, Genc, Omer, Gungor, Baris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977078/
https://www.ncbi.nlm.nih.gov/pubmed/34812131
http://dx.doi.org/10.17305/bjbms.2021.6577
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author Alici, Gokhan
Barman, Hasan Ali
Asoglu, Ramazan
Atici, Adem
Akciger, Atike Nazli
Sit, Omer
Dogan, Omer
Yavuz, Yucel
Borahan, Songul
Genc, Omer
Gungor, Baris
author_facet Alici, Gokhan
Barman, Hasan Ali
Asoglu, Ramazan
Atici, Adem
Akciger, Atike Nazli
Sit, Omer
Dogan, Omer
Yavuz, Yucel
Borahan, Songul
Genc, Omer
Gungor, Baris
author_sort Alici, Gokhan
collection PubMed
description The aim of this study was to investigate the patient characteristics and laboratory parameters for coronavirus disease-2019 (COVID-19) non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died of COVID-19 in our intensive care unit were collected in the period of March 20, 2020-April 30, 2020. D-dimer, platelet count, C-reactive protein (CRP), high-sensitivity Troponin I (hs-TnI), and international normalized ratio (INR) levels were recorded on the 1(st), 5(th), and 10(th) days of hospitalization to investigate the possible correlation of laboratory parameter changes with in-hospital events. A total of 161 non-survivors patients with COVID-19 were included in the study. The median age was 69.8 ± 10.9 years, and 95 (59%) of the population were male. Lung-related complications were the most common in-hospital complications. Patients with COVID-19 had in-hospital complications such as major bleeding (39%), hemoptysis (14%), disseminated intravascular coagulation (DIC) (13%), liver failure (21%), acute respiratory distress syndrome (ARDS) (85%), acute kidney injury (AKI) (40%), and myocardial injury (70%). A multiple logistics regression analysis determined that age, hypertension (HT), diabetes mellitus (DM), use of acetylsalicylic acid or low-molecular-weight heparin (LMWH), hemoglobin, D-dimer, INR, and AKI were independent predictors of major bleeding. Our results showed that a high proportion of COVID-19 non-survivors suffered from major bleeding complications.
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spelling pubmed-89770782022-04-14 Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study Alici, Gokhan Barman, Hasan Ali Asoglu, Ramazan Atici, Adem Akciger, Atike Nazli Sit, Omer Dogan, Omer Yavuz, Yucel Borahan, Songul Genc, Omer Gungor, Baris Bosn J Basic Med Sci Research Article The aim of this study was to investigate the patient characteristics and laboratory parameters for coronavirus disease-2019 (COVID-19) non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died of COVID-19 in our intensive care unit were collected in the period of March 20, 2020-April 30, 2020. D-dimer, platelet count, C-reactive protein (CRP), high-sensitivity Troponin I (hs-TnI), and international normalized ratio (INR) levels were recorded on the 1(st), 5(th), and 10(th) days of hospitalization to investigate the possible correlation of laboratory parameter changes with in-hospital events. A total of 161 non-survivors patients with COVID-19 were included in the study. The median age was 69.8 ± 10.9 years, and 95 (59%) of the population were male. Lung-related complications were the most common in-hospital complications. Patients with COVID-19 had in-hospital complications such as major bleeding (39%), hemoptysis (14%), disseminated intravascular coagulation (DIC) (13%), liver failure (21%), acute respiratory distress syndrome (ARDS) (85%), acute kidney injury (AKI) (40%), and myocardial injury (70%). A multiple logistics regression analysis determined that age, hypertension (HT), diabetes mellitus (DM), use of acetylsalicylic acid or low-molecular-weight heparin (LMWH), hemoglobin, D-dimer, INR, and AKI were independent predictors of major bleeding. Our results showed that a high proportion of COVID-19 non-survivors suffered from major bleeding complications. Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2022-04 2021-11-22 /pmc/articles/PMC8977078/ /pubmed/34812131 http://dx.doi.org/10.17305/bjbms.2021.6577 Text en Copyright: © The Author(s) (2022) https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Research Article
Alici, Gokhan
Barman, Hasan Ali
Asoglu, Ramazan
Atici, Adem
Akciger, Atike Nazli
Sit, Omer
Dogan, Omer
Yavuz, Yucel
Borahan, Songul
Genc, Omer
Gungor, Baris
Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study
title Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study
title_full Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study
title_fullStr Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study
title_full_unstemmed Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study
title_short Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study
title_sort clinical features and major bleeding predictors for 161 fatal cases of covid-19: a retrospective observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977078/
https://www.ncbi.nlm.nih.gov/pubmed/34812131
http://dx.doi.org/10.17305/bjbms.2021.6577
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