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Central airway obstruction treatment with self‐expanding covered Y‐carina nitinol stents: A single center retrospective analysis

BACKGROUND: Central airway obstruction (CAO) is one of the most challenging, potentially lethal complications in malignant and benign respiratory diseases. Worsening dyspnea is also a relevant cause for reduced quality of life in such patients. Here, we present our data on the application of covered...

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Autores principales: Schulze, Arik Bernard, Evers, Georg, Tenk, Friederike Sophia, Schliemann, Christoph, Schmidt, Lars Henning, Görlich, Dennis, Mohr, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977163/
https://www.ncbi.nlm.nih.gov/pubmed/35199949
http://dx.doi.org/10.1111/1759-7714.14359
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author Schulze, Arik Bernard
Evers, Georg
Tenk, Friederike Sophia
Schliemann, Christoph
Schmidt, Lars Henning
Görlich, Dennis
Mohr, Michael
author_facet Schulze, Arik Bernard
Evers, Georg
Tenk, Friederike Sophia
Schliemann, Christoph
Schmidt, Lars Henning
Görlich, Dennis
Mohr, Michael
author_sort Schulze, Arik Bernard
collection PubMed
description BACKGROUND: Central airway obstruction (CAO) is one of the most challenging, potentially lethal complications in malignant and benign respiratory diseases. Worsening dyspnea is also a relevant cause for reduced quality of life in such patients. Here, we present our data on the application of covered, self‐expanding Y‐carina nitinol stents due to benign and malignant diseases. METHODS: We retrospectively identified 27 patients who had undergone 31 rigid bronchoscopies with implantation of covered Y‐carina nitinol stents over a period of 10 years in order to evaluate indication, clinical course, and outcome. RESULTS: Short‐term survival of successfully stented patients with palliative and curative treatment goal did not differ, allowing for diagnosis independent indication. With respect to overall survival, patients with endoluminal obstruction benefited most compared to patients with fistula and/or external compression. Granulation tissue formation (61.3%) and mucus plugging (80.6%) were the most frequent complications. Material defect (6.5%) and migration (3.2%) were rare complications that could be handled by revisional rigid bronchoscopy and stent exchange in some cases. CONCLUSIONS: Implantation of self‐expanding covered Y‐carina nitinol stents via rigid bronchoscopy is a feasible and safe treatment option for benign and malignant central airway obstruction. Especially in palliative, malignant airway stenosis, stenting might facilitate additional treatment options and optimize dyspnea and eventually quality of life.
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spelling pubmed-89771632022-04-05 Central airway obstruction treatment with self‐expanding covered Y‐carina nitinol stents: A single center retrospective analysis Schulze, Arik Bernard Evers, Georg Tenk, Friederike Sophia Schliemann, Christoph Schmidt, Lars Henning Görlich, Dennis Mohr, Michael Thorac Cancer Original Articles BACKGROUND: Central airway obstruction (CAO) is one of the most challenging, potentially lethal complications in malignant and benign respiratory diseases. Worsening dyspnea is also a relevant cause for reduced quality of life in such patients. Here, we present our data on the application of covered, self‐expanding Y‐carina nitinol stents due to benign and malignant diseases. METHODS: We retrospectively identified 27 patients who had undergone 31 rigid bronchoscopies with implantation of covered Y‐carina nitinol stents over a period of 10 years in order to evaluate indication, clinical course, and outcome. RESULTS: Short‐term survival of successfully stented patients with palliative and curative treatment goal did not differ, allowing for diagnosis independent indication. With respect to overall survival, patients with endoluminal obstruction benefited most compared to patients with fistula and/or external compression. Granulation tissue formation (61.3%) and mucus plugging (80.6%) were the most frequent complications. Material defect (6.5%) and migration (3.2%) were rare complications that could be handled by revisional rigid bronchoscopy and stent exchange in some cases. CONCLUSIONS: Implantation of self‐expanding covered Y‐carina nitinol stents via rigid bronchoscopy is a feasible and safe treatment option for benign and malignant central airway obstruction. Especially in palliative, malignant airway stenosis, stenting might facilitate additional treatment options and optimize dyspnea and eventually quality of life. John Wiley & Sons Australia, Ltd 2022-02-24 2022-04 /pmc/articles/PMC8977163/ /pubmed/35199949 http://dx.doi.org/10.1111/1759-7714.14359 Text en © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Schulze, Arik Bernard
Evers, Georg
Tenk, Friederike Sophia
Schliemann, Christoph
Schmidt, Lars Henning
Görlich, Dennis
Mohr, Michael
Central airway obstruction treatment with self‐expanding covered Y‐carina nitinol stents: A single center retrospective analysis
title Central airway obstruction treatment with self‐expanding covered Y‐carina nitinol stents: A single center retrospective analysis
title_full Central airway obstruction treatment with self‐expanding covered Y‐carina nitinol stents: A single center retrospective analysis
title_fullStr Central airway obstruction treatment with self‐expanding covered Y‐carina nitinol stents: A single center retrospective analysis
title_full_unstemmed Central airway obstruction treatment with self‐expanding covered Y‐carina nitinol stents: A single center retrospective analysis
title_short Central airway obstruction treatment with self‐expanding covered Y‐carina nitinol stents: A single center retrospective analysis
title_sort central airway obstruction treatment with self‐expanding covered y‐carina nitinol stents: a single center retrospective analysis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977163/
https://www.ncbi.nlm.nih.gov/pubmed/35199949
http://dx.doi.org/10.1111/1759-7714.14359
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