Cargando…

Network Pharmacology Integrated with Transcriptomics Deciphered the Potential Mechanism of Codonopsis pilosula against Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the fourth main reason of cancer-related death. Codonopsis pilosula is a commonly used traditional Chinese medicine (TCM) for patients with HCC. However, its potential mechanism for treatment of HCC remains unclear. Here, we used transcriptomics and network pharmaco...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zhili, Sun, Yuzhe, Zhen, Hefu, Nie, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977304/ https://www.ncbi.nlm.nih.gov/pubmed/35388300 http://dx.doi.org/10.1155/2022/1340194

Ejemplares similares

Integrating Network Pharmacology and Bioinformatics to Explore the Effects of Dangshen (Codonopsis pilosula) Against Hepatocellular Carcinoma: Validation Based on the Active Compound Luteolin
por: Yu, Yaping, et al.
Publicado: (2023)

Sesquiterpene glycosides from the roots of Codonopsis pilosula
por: Jiang, Yueping, et al.
Publicado: (2016)

Acetylenes and fatty acids from Codonopsis pilosula
por: Jiang, Yueping, et al.
Publicado: (2015)

Characterization of Codonopsis pilosula subsp. tangshen plastome and comparative analysis of Codonopsis species
por: Yue, Jingwen, et al.
Publicado: (2022)

Two New Triterpenoids from the Roots of Codonopsis pilosula
por: Zheng, Tao, et al.
Publicado: (2018)

Transcriptome Sequencing of Codonopsis pilosula and Identification of Candidate Genes Involved in Polysaccharide Biosynthesis
por: Gao, Jian Ping, et al.
Publicado: (2015)

Predictive Study of the Active Ingredients and Potential Targets of Codonopsis pilosula for the Treatment of Osteosarcoma via Network Pharmacology
por: Gong, Yu-Bao, et al.
Publicado: (2021)

Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism
por: Hu, Xiao-Yu, et al.
Publicado: (2018)

Extraction of polysaccharides from Codonopsis pilosula by fermentation with response surface methodology
por: Yuan, Shuai, et al.
Publicado: (2020)

Stimulation of Codonopsis pilosula Polysaccharide on Bifidobacterium of Human Gut Bacteria In Vitro
por: Li, Jiankuan, et al.
Publicado: (2021)

Antimicrobial activity and enzymatic analysis of endophytes isolated from Codonopsis pilosula
por: Lodi, Rathna Silviya, et al.
Publicado: (2023)

Selection and Validation of Reference Genes for Gene Expression Studies in Codonopsis pilosula Based on Transcriptome Sequence Data
por: Liang, Lijun, et al.
Publicado: (2020)

Ultrasonic-Assisted Extraction of Codonopsis pilosula Glucofructan: Optimization, Structure, and Immunoregulatory Activity
por: Ji, Hai-Yu, et al.
Publicado: (2022)

Effects of Different Drying Methods on the Drying Characteristics and Quality of Codonopsis pilosulae Slices
por: Yue, Yuanman, et al.
Publicado: (2023)

A Polysaccharide Isolated from Codonopsis pilosula with Immunomodulation Effects Both In Vitro and In Vivo
por: Zou, Yuan-Feng, et al.
Publicado: (2019)

Solomonseal Polysaccharide and Sulfated Codonopsis pilosula Polysaccharide Synergistically Resist Newcastle Disease Virus
por: Liu, Cui, et al.
Publicado: (2015)

Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells
por: Ko, Pin-Hao, et al.
Publicado: (2019)

Response of Bioactive Metabolite and Biosynthesis Related Genes to Methyl Jasmonate Elicitation in Codonopsis pilosula
por: Ji, Jiao-jiao, et al.
Publicado: (2019)

The Effect and Mechanism of New Processing Method of Codonopsis pilosula on Endocrine Physique Index in Rats
por: Gong, Xiaomeng, et al.
Publicado: (2022)

Extraction, structural characterization, and biological activities of a new glucan from Codonopsis pilosula
por: Lu, Shanshan, et al.
Publicado: (2023)

Systemic Immunomodulatory Effects of Codonopsis pilosula Glucofructan on S180 Solid-Tumor-Bearing Mice
por: Fan, Yuting, et al.
Publicado: (2023)

The Polysaccharides from Codonopsis pilosula Modulates the Immunity and Intestinal Microbiota of Cyclophosphamide-Treated Immunosuppressed Mice
por: Fu, Yu-Ping, et al.
Publicado: (2018)

Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula
por: Qin, Fu-Ying, et al.
Publicado: (2018)

Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice
por: Zhang, Qing, et al.
Publicado: (2018)

Untargeted Metabolomics Reveals Multiple Phytometabolites in the Agricultural Waste Materials and Medicinal Materials of Codonopsis pilosula
por: Zeng, Xu, et al.
Publicado: (2022)

Isolation, Purification, and Structural Characterization of Polysaccharides from Codonopsis pilosula and Their Anti-Tumor Bioactivity by Immunomodulation
por: Li, Nan, et al.
Publicado: (2023)

Retracted: The Effect and Mechanism of New Processing Method of Codonopsis pilosula on Endocrine Physique Index in Rats
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Exopolysaccharides from a Codonopsis pilosula endophyte activate macrophages and inhibit cancer cell proliferation and migration
por: Chen, Min, et al.
Publicado: (2018)

Codonopsis pilosula polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice
por: Wan, Lu, et al.
Publicado: (2020)

Codonopsis pilosula Polysaccharide Improved Spleen Deficiency in Mice by Modulating Gut Microbiota and Energy Related Metabolisms
por: Cao, Lingya, et al.
Publicado: (2022)

Structural features and antioxidant activities of polysaccharides from different parts of Codonopsis pilosula var. modesta (Nannf.) L. T. Shen
por: Li, Li-Xia, et al.
Publicado: (2022)

Three Inulin-Type Fructans from Codonopsis pilosula (Franch.) Nannf. Roots and Their Prebiotic Activity on Bifidobacterium longum
por: Li, Jiankuan, et al.
Publicado: (2018)

Contents of lobetyolin, syringin, and atractylolide III in Codonopsis pilosula are related to dynamic changes of endophytes under drought stress
por: Liang, Yichuan, et al.
Publicado: (2021)

The Obesity Amelioration Effect in High-Fat-Diet Fed Mice of a Homogeneous Polysaccharide from Codonopsis pilosula
por: Su, Qi, et al.
Publicado: (2022)

Response surface methodology for the mixed fungal fermentation of Codonopsis pilosula straw using Trichoderma reesei and Coprinus comatus
por: Wei, Ti, et al.
Publicado: (2023)

Restorative Effects of Inulin From Codonopsis pilosula on Intestinal Mucosal Immunity, Anti-Inflammatory Activity and Gut Microbiota of Immunosuppressed Mice
por: Zou, Yuan-Feng, et al.
Publicado: (2022)

The inhibitory effect of phosphorylated Codonopsis pilosula polysaccharide on autophagosomes formation contributes to the inhibition of duck hepatitis A virus replication
por: Ming, Ke, et al.
Publicado: (2020)

First report of potato rot nematode, Ditylenchus destructor Thorne, 1945 infecting Codonopsis pilosula in Gansu province, China
por: Ni, Chunhui, et al.
Publicado: (2020)

Bio-guided isolation of plant growth regulators from allelopathic plant-Codonopsis pilosula: phyto-selective activities and mechanisms
por: Xie, Min, et al.
Publicado: (2018)

Herbal Extract from Codonopsis pilosula (Franch.) Nannf. Enhances Cardiogenic Differentiation and Improves the Function of Infarcted Rat Hearts
por: Wang, Jieh-Neng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2prcfo65hql447v49ed4ta1ma4