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Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.
Fungal infections are estimated to be the main cause of death for more than 1.5 million people worldwide annually. However, fungal pathogenicity has been largely neglected. This is notably the case for pulmonary fungal infections, which are difficult to diagnose and to treat. We are currently facing...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977413/ https://www.ncbi.nlm.nih.gov/pubmed/35386908 http://dx.doi.org/10.3389/fmed.2022.832510 |
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author | Palmieri, Fabio Koutsokera, Angela Bernasconi, Eric Junier, Pilar von Garnier, Christophe Ubags, Niki |
author_facet | Palmieri, Fabio Koutsokera, Angela Bernasconi, Eric Junier, Pilar von Garnier, Christophe Ubags, Niki |
author_sort | Palmieri, Fabio |
collection | PubMed |
description | Fungal infections are estimated to be the main cause of death for more than 1.5 million people worldwide annually. However, fungal pathogenicity has been largely neglected. This is notably the case for pulmonary fungal infections, which are difficult to diagnose and to treat. We are currently facing a global emergence of antifungal resistance, which decreases the chances of survival for affected patients. New therapeutic approaches are therefore needed to face these life-threatening fungal infections. In this review, we will provide a general overview on respiratory fungal infections, with a focus on fungi of the genus Aspergillus. Next, the immunological and microbiological mechanisms of fungal pathogenesis will be discussed. The role of the respiratory mycobiota and its interactions with the bacterial microbiota on lung fungal infections will be presented from an ecological perspective. Finally, we will focus on existing and future innovative approaches for the treatment of respiratory fungal infections. |
format | Online Article Text |
id | pubmed-8977413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89774132022-04-05 Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp. Palmieri, Fabio Koutsokera, Angela Bernasconi, Eric Junier, Pilar von Garnier, Christophe Ubags, Niki Front Med (Lausanne) Medicine Fungal infections are estimated to be the main cause of death for more than 1.5 million people worldwide annually. However, fungal pathogenicity has been largely neglected. This is notably the case for pulmonary fungal infections, which are difficult to diagnose and to treat. We are currently facing a global emergence of antifungal resistance, which decreases the chances of survival for affected patients. New therapeutic approaches are therefore needed to face these life-threatening fungal infections. In this review, we will provide a general overview on respiratory fungal infections, with a focus on fungi of the genus Aspergillus. Next, the immunological and microbiological mechanisms of fungal pathogenesis will be discussed. The role of the respiratory mycobiota and its interactions with the bacterial microbiota on lung fungal infections will be presented from an ecological perspective. Finally, we will focus on existing and future innovative approaches for the treatment of respiratory fungal infections. Frontiers Media S.A. 2022-03-21 /pmc/articles/PMC8977413/ /pubmed/35386908 http://dx.doi.org/10.3389/fmed.2022.832510 Text en Copyright © 2022 Palmieri, Koutsokera, Bernasconi, Junier, von Garnier and Ubags. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Palmieri, Fabio Koutsokera, Angela Bernasconi, Eric Junier, Pilar von Garnier, Christophe Ubags, Niki Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp. |
title | Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp. |
title_full | Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp. |
title_fullStr | Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp. |
title_full_unstemmed | Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp. |
title_short | Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp. |
title_sort | recent advances in fungal infections: from lung ecology to therapeutic strategies with a focus on aspergillus spp. |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977413/ https://www.ncbi.nlm.nih.gov/pubmed/35386908 http://dx.doi.org/10.3389/fmed.2022.832510 |
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