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Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.

Fungal infections are estimated to be the main cause of death for more than 1.5 million people worldwide annually. However, fungal pathogenicity has been largely neglected. This is notably the case for pulmonary fungal infections, which are difficult to diagnose and to treat. We are currently facing...

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Autores principales: Palmieri, Fabio, Koutsokera, Angela, Bernasconi, Eric, Junier, Pilar, von Garnier, Christophe, Ubags, Niki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977413/
https://www.ncbi.nlm.nih.gov/pubmed/35386908
http://dx.doi.org/10.3389/fmed.2022.832510
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author Palmieri, Fabio
Koutsokera, Angela
Bernasconi, Eric
Junier, Pilar
von Garnier, Christophe
Ubags, Niki
author_facet Palmieri, Fabio
Koutsokera, Angela
Bernasconi, Eric
Junier, Pilar
von Garnier, Christophe
Ubags, Niki
author_sort Palmieri, Fabio
collection PubMed
description Fungal infections are estimated to be the main cause of death for more than 1.5 million people worldwide annually. However, fungal pathogenicity has been largely neglected. This is notably the case for pulmonary fungal infections, which are difficult to diagnose and to treat. We are currently facing a global emergence of antifungal resistance, which decreases the chances of survival for affected patients. New therapeutic approaches are therefore needed to face these life-threatening fungal infections. In this review, we will provide a general overview on respiratory fungal infections, with a focus on fungi of the genus Aspergillus. Next, the immunological and microbiological mechanisms of fungal pathogenesis will be discussed. The role of the respiratory mycobiota and its interactions with the bacterial microbiota on lung fungal infections will be presented from an ecological perspective. Finally, we will focus on existing and future innovative approaches for the treatment of respiratory fungal infections.
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spelling pubmed-89774132022-04-05 Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp. Palmieri, Fabio Koutsokera, Angela Bernasconi, Eric Junier, Pilar von Garnier, Christophe Ubags, Niki Front Med (Lausanne) Medicine Fungal infections are estimated to be the main cause of death for more than 1.5 million people worldwide annually. However, fungal pathogenicity has been largely neglected. This is notably the case for pulmonary fungal infections, which are difficult to diagnose and to treat. We are currently facing a global emergence of antifungal resistance, which decreases the chances of survival for affected patients. New therapeutic approaches are therefore needed to face these life-threatening fungal infections. In this review, we will provide a general overview on respiratory fungal infections, with a focus on fungi of the genus Aspergillus. Next, the immunological and microbiological mechanisms of fungal pathogenesis will be discussed. The role of the respiratory mycobiota and its interactions with the bacterial microbiota on lung fungal infections will be presented from an ecological perspective. Finally, we will focus on existing and future innovative approaches for the treatment of respiratory fungal infections. Frontiers Media S.A. 2022-03-21 /pmc/articles/PMC8977413/ /pubmed/35386908 http://dx.doi.org/10.3389/fmed.2022.832510 Text en Copyright © 2022 Palmieri, Koutsokera, Bernasconi, Junier, von Garnier and Ubags. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Palmieri, Fabio
Koutsokera, Angela
Bernasconi, Eric
Junier, Pilar
von Garnier, Christophe
Ubags, Niki
Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.
title Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.
title_full Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.
title_fullStr Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.
title_full_unstemmed Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.
title_short Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.
title_sort recent advances in fungal infections: from lung ecology to therapeutic strategies with a focus on aspergillus spp.
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977413/
https://www.ncbi.nlm.nih.gov/pubmed/35386908
http://dx.doi.org/10.3389/fmed.2022.832510
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