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Point Mutations in the FLT3-ITD Region Are Rare but Recurrent Alterations in Adult AML and Associated With Concomitant KMT2A-PTD

FLT3-ITD mutations are common druggable alterations in patients with acute myeloid leukemia (AML) and associated with poor prognosis. Beside typical ITD mutations, point mutations and deletions in the juxtamembrane domain (JMD) have been observed. However, due to the low frequency of these alteratio...

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Detalles Bibliográficos
Autores principales:	Stasik, Sebastian, Kramer, Michael, Zukunft, Sven, Röllig, Christoph, Baldus, Claudia D., Platzbecker, Uwe, Serve, Hubert, Müller-Tidow, Carsten, Schäfer-Eckart, Kerstin, Kaufmann, Martin, Krause, Stefan, Sauer, Tim, Hänel, Mathias, Neubauer, Andreas, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, Middeke, Jan M., Thiede, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977490/ https://www.ncbi.nlm.nih.gov/pubmed/35387132 http://dx.doi.org/10.3389/fonc.2022.862991

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