Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection

The human immunological mechanisms defining the clinical outcome of SARS-CoV-2 infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate experimental platforms recapitulating human immune responses in a controlled human lung environment. Here, we report a mouse model (...

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Autores principales: Kenney, Devin J., O’Connell, Aoife K., Turcinovic, Jacquelyn, Montanaro, Paige, Hekman, Ryan M., Tamura, Tomokazu, Berneshawi, Andrew R., Cafiero, Thomas R., Al Abdullatif, Salam, Blum, Benjamin, Goldstein, Stanley I., Heller, Brigitte L., Gertje, Hans P., Bullitt, Esther, Trachtenberg, Alexander J., Chavez, Elizabeth, Nono, Evans Tuekam, Morrison, Catherine, Tseng, Anna E., Sheikh, Amira, Kurnick, Susanna, Grosz, Kyle, Bosmann, Markus, Ericsson, Maria, Huber, Bertrand R., Saeed, Mohsan, Balazs, Alejandro B., Francis, Kevin P., Klose, Alexander, Paragas, Neal, Campbell, Joshua D., Connor, John H., Emili, Andrew, Crossland, Nicholas A., Ploss, Alexander, Douam, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2022
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977517/
https://www.ncbi.nlm.nih.gov/pubmed/35421379
http://dx.doi.org/10.1016/j.celrep.2022.110714

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