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Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis

BACKGROUND: Catechol-O-methyltransferase (COMT) contributes to the control of synaptic dopamine (DA) transmission by catalyzing DA degradation in the presynaptic space. The COMT Val158Met polymorphism (rs4680) substantially alters enzymatic activity and consequently synaptic DA concentration in the...

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Detalles Bibliográficos
Autores principales:	Ma, Jingsong, Zhao, Mingzhe, Zhou, Wei, Li, Mo, Huai, Cong, Shen, Lu, Wang, Ting, Wu, Hao, Zhang, Na, Zhang, Zhiruo, He, Lin, Qin, Shengying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977635/ https://www.ncbi.nlm.nih.gov/pubmed/33100205 http://dx.doi.org/10.2174/1570159X18666201023154049

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