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Causal Association and Shared Genetics Between Asthma and COVID-19

OBJECTIVES: Recent studies suggest that asthma may have a protective effect on COVID-19.We aimed to investigate the causality between asthma and two COVID-19 outcomes and explore the mechanisms underlining this connection. METHODS: Summary results of GWAS were used for the analyses, including asthma...

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Autores principales: Baranova, Ancha, Cao, Hongbao, Chen, Jiu, Zhang, Fuquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977836/
https://www.ncbi.nlm.nih.gov/pubmed/35386719
http://dx.doi.org/10.3389/fimmu.2022.705379
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author Baranova, Ancha
Cao, Hongbao
Chen, Jiu
Zhang, Fuquan
author_facet Baranova, Ancha
Cao, Hongbao
Chen, Jiu
Zhang, Fuquan
author_sort Baranova, Ancha
collection PubMed
description OBJECTIVES: Recent studies suggest that asthma may have a protective effect on COVID-19.We aimed to investigate the causality between asthma and two COVID-19 outcomes and explore the mechanisms underlining this connection. METHODS: Summary results of GWAS were used for the analyses, including asthma (88,486 cases and 447,859 controls), COVID-19 hospitalization (6,406 hospitalized COVID-19 cases and 902,088 controls), and COVID-19 infection (14,134 COVID-19 cases and 1,284,876 controls). The Mendelian randomization (MR) analysis was performed to evaluate the causal effects of asthma on the two COVID-19 outcomes. A cross-trait meta-analysis was conducted to analyze genetic variants within two loci shared by COVID-19 hospitalization and asthma. RESULTS: Asthma is associated with decreased risk both for COVID-19 hospitalization (odds ratio (OR): 0.70, 95% confidence interval (CI): 0.70-0.99) and for COVID-19 infection (OR: 0.83, 95%CI: 0.51-0.95). Asthma and COVID-19 share two genome-wide significant genes, including ABO at the 9q34.2 region and OAS2 at the 12q24.13 region. The meta-analysis revealed that ABO and ATXN2 contain variants with pleiotropic effects on both COVID-19 and asthma. CONCLUSION: In conclusion, our results suggest that genetic liability to asthma is associated with decreased susceptibility to SARS-CoV-2 and to severe COVID-19 disease, which may be due to the protective effects of ongoing inflammation and, possibly, related compensatory responses against COVID-19 in its early stage.
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spelling pubmed-89778362022-04-05 Causal Association and Shared Genetics Between Asthma and COVID-19 Baranova, Ancha Cao, Hongbao Chen, Jiu Zhang, Fuquan Front Immunol Immunology OBJECTIVES: Recent studies suggest that asthma may have a protective effect on COVID-19.We aimed to investigate the causality between asthma and two COVID-19 outcomes and explore the mechanisms underlining this connection. METHODS: Summary results of GWAS were used for the analyses, including asthma (88,486 cases and 447,859 controls), COVID-19 hospitalization (6,406 hospitalized COVID-19 cases and 902,088 controls), and COVID-19 infection (14,134 COVID-19 cases and 1,284,876 controls). The Mendelian randomization (MR) analysis was performed to evaluate the causal effects of asthma on the two COVID-19 outcomes. A cross-trait meta-analysis was conducted to analyze genetic variants within two loci shared by COVID-19 hospitalization and asthma. RESULTS: Asthma is associated with decreased risk both for COVID-19 hospitalization (odds ratio (OR): 0.70, 95% confidence interval (CI): 0.70-0.99) and for COVID-19 infection (OR: 0.83, 95%CI: 0.51-0.95). Asthma and COVID-19 share two genome-wide significant genes, including ABO at the 9q34.2 region and OAS2 at the 12q24.13 region. The meta-analysis revealed that ABO and ATXN2 contain variants with pleiotropic effects on both COVID-19 and asthma. CONCLUSION: In conclusion, our results suggest that genetic liability to asthma is associated with decreased susceptibility to SARS-CoV-2 and to severe COVID-19 disease, which may be due to the protective effects of ongoing inflammation and, possibly, related compensatory responses against COVID-19 in its early stage. Frontiers Media S.A. 2022-03-21 /pmc/articles/PMC8977836/ /pubmed/35386719 http://dx.doi.org/10.3389/fimmu.2022.705379 Text en Copyright © 2022 Baranova, Cao, Chen and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Baranova, Ancha
Cao, Hongbao
Chen, Jiu
Zhang, Fuquan
Causal Association and Shared Genetics Between Asthma and COVID-19
title Causal Association and Shared Genetics Between Asthma and COVID-19
title_full Causal Association and Shared Genetics Between Asthma and COVID-19
title_fullStr Causal Association and Shared Genetics Between Asthma and COVID-19
title_full_unstemmed Causal Association and Shared Genetics Between Asthma and COVID-19
title_short Causal Association and Shared Genetics Between Asthma and COVID-19
title_sort causal association and shared genetics between asthma and covid-19
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977836/
https://www.ncbi.nlm.nih.gov/pubmed/35386719
http://dx.doi.org/10.3389/fimmu.2022.705379
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