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Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE

SIGNIFICANCE: Open-source software packages have been extensively used in the past three decades in medical imaging and diagnostics, aiming to study the feasibility of the application ex vivo. Unfortunately, most of the existing open-source tools require some software engineering background to insta...

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Autores principales: Wang, Shuran, Dai, Xiao Ying, Ji, Shengxiang, Saeidi, Tina, Schwiegelshohn, Fynn, Yassine, Abdul-Amir, Lilge, Lothar, Betz, Vaughn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978262/
https://www.ncbi.nlm.nih.gov/pubmed/35380030
http://dx.doi.org/10.1117/1.JBO.27.8.083006
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author Wang, Shuran
Dai, Xiao Ying
Ji, Shengxiang
Saeidi, Tina
Schwiegelshohn, Fynn
Yassine, Abdul-Amir
Lilge, Lothar
Betz, Vaughn
author_facet Wang, Shuran
Dai, Xiao Ying
Ji, Shengxiang
Saeidi, Tina
Schwiegelshohn, Fynn
Yassine, Abdul-Amir
Lilge, Lothar
Betz, Vaughn
author_sort Wang, Shuran
collection PubMed
description SIGNIFICANCE: Open-source software packages have been extensively used in the past three decades in medical imaging and diagnostics, aiming to study the feasibility of the application ex vivo. Unfortunately, most of the existing open-source tools require some software engineering background to install the prerequisite libraries, choose a suitable computational platform, and combine several software tools to address different applications. AIM: To facilitate the use of open-source software in medical applications, enabling computational studies of treatment outcomes prior to the complex in-vivo setting. APPROACH: FullMonteWeb, an open-source, user-friendly web-based software with a graphical user interface for interstitial photodynamic therapy (iPDT) modeling, visualization, and optimization, is introduced. The software can perform Monte Carlo simulations of light propagation in biological tissues, along with iPDT plan optimization. FullMonteWeb installs and runs the required software and libraries on Amazon Web Services (AWS), allowing scalable computing without complex set up. RESULTS: FullMonteWeb allows simulation of large and small problems on the most appropriate compute hardware, enabling cost improvements of [Formula: see text] versus always running on a single platform. Case studies in optical property estimation and diffuser placement optimization highlight FullMonteWeb’s versatility. CONCLUSION: The FullMonte open source suite enables easier and more cost-effective in-silico studies for iPDT.
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spelling pubmed-89782622022-04-05 Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE Wang, Shuran Dai, Xiao Ying Ji, Shengxiang Saeidi, Tina Schwiegelshohn, Fynn Yassine, Abdul-Amir Lilge, Lothar Betz, Vaughn J Biomed Opt Special Section Celebrating 30 Years of Open Source Monte Carlo Codes in Biomedical Optics SIGNIFICANCE: Open-source software packages have been extensively used in the past three decades in medical imaging and diagnostics, aiming to study the feasibility of the application ex vivo. Unfortunately, most of the existing open-source tools require some software engineering background to install the prerequisite libraries, choose a suitable computational platform, and combine several software tools to address different applications. AIM: To facilitate the use of open-source software in medical applications, enabling computational studies of treatment outcomes prior to the complex in-vivo setting. APPROACH: FullMonteWeb, an open-source, user-friendly web-based software with a graphical user interface for interstitial photodynamic therapy (iPDT) modeling, visualization, and optimization, is introduced. The software can perform Monte Carlo simulations of light propagation in biological tissues, along with iPDT plan optimization. FullMonteWeb installs and runs the required software and libraries on Amazon Web Services (AWS), allowing scalable computing without complex set up. RESULTS: FullMonteWeb allows simulation of large and small problems on the most appropriate compute hardware, enabling cost improvements of [Formula: see text] versus always running on a single platform. Case studies in optical property estimation and diffuser placement optimization highlight FullMonteWeb’s versatility. CONCLUSION: The FullMonte open source suite enables easier and more cost-effective in-silico studies for iPDT. Society of Photo-Optical Instrumentation Engineers 2022-04-04 2022-08 /pmc/articles/PMC8978262/ /pubmed/35380030 http://dx.doi.org/10.1117/1.JBO.27.8.083006 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Special Section Celebrating 30 Years of Open Source Monte Carlo Codes in Biomedical Optics
Wang, Shuran
Dai, Xiao Ying
Ji, Shengxiang
Saeidi, Tina
Schwiegelshohn, Fynn
Yassine, Abdul-Amir
Lilge, Lothar
Betz, Vaughn
Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE
title Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE
title_full Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE
title_fullStr Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE
title_full_unstemmed Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE
title_short Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE
title_sort scalable and accessible personalized photodynamic therapy optimization with fullmonte and pdt-space
topic Special Section Celebrating 30 Years of Open Source Monte Carlo Codes in Biomedical Optics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978262/
https://www.ncbi.nlm.nih.gov/pubmed/35380030
http://dx.doi.org/10.1117/1.JBO.27.8.083006
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