Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties

Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death globally. Enhanced chronic inflammation and pathological remodeling are the main consequences of COPD, leading to decreased life span. Histological and molecular investigations revealed that prominent imm...

Descripción completa

Detalles Bibliográficos
Autores principales: Rajabi, Hadi, Konyalilar, Nur, Erkan, Sinem, Mortazavi, Deniz, Korkunc, Seval Kubra, Kayalar, Ozgecan, Bayram, Hasan, Rahbarghazi, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978512/
https://www.ncbi.nlm.nih.gov/pubmed/35379335
http://dx.doi.org/10.1186/s13287-022-02820-4
_version_ 1784680980029636608
author Rajabi, Hadi
Konyalilar, Nur
Erkan, Sinem
Mortazavi, Deniz
Korkunc, Seval Kubra
Kayalar, Ozgecan
Bayram, Hasan
Rahbarghazi, Reza
author_facet Rajabi, Hadi
Konyalilar, Nur
Erkan, Sinem
Mortazavi, Deniz
Korkunc, Seval Kubra
Kayalar, Ozgecan
Bayram, Hasan
Rahbarghazi, Reza
author_sort Rajabi, Hadi
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death globally. Enhanced chronic inflammation and pathological remodeling are the main consequences of COPD, leading to decreased life span. Histological and molecular investigations revealed that prominent immune cell infiltration and release of several cytokines contribute to progressive chronic remodeling. Recent investigations have revealed that exosomes belonging to extracellular vesicles are involved in the pathogenesis of COPD. It has been elucidated that exosomes secreted from immune cells are eligible to carry numerous pro-inflammatory factors exacerbating the pathological conditions. Here, in this review article, we have summarized various and reliable information about the negative role of immune cell-derived exosomes in the remodeling of pulmonary tissue and airways destruction in COPD patients.
format Online
Article
Text
id pubmed-8978512
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-89785122022-04-04 Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties Rajabi, Hadi Konyalilar, Nur Erkan, Sinem Mortazavi, Deniz Korkunc, Seval Kubra Kayalar, Ozgecan Bayram, Hasan Rahbarghazi, Reza Stem Cell Res Ther Review Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death globally. Enhanced chronic inflammation and pathological remodeling are the main consequences of COPD, leading to decreased life span. Histological and molecular investigations revealed that prominent immune cell infiltration and release of several cytokines contribute to progressive chronic remodeling. Recent investigations have revealed that exosomes belonging to extracellular vesicles are involved in the pathogenesis of COPD. It has been elucidated that exosomes secreted from immune cells are eligible to carry numerous pro-inflammatory factors exacerbating the pathological conditions. Here, in this review article, we have summarized various and reliable information about the negative role of immune cell-derived exosomes in the remodeling of pulmonary tissue and airways destruction in COPD patients. BioMed Central 2022-04-04 /pmc/articles/PMC8978512/ /pubmed/35379335 http://dx.doi.org/10.1186/s13287-022-02820-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Rajabi, Hadi
Konyalilar, Nur
Erkan, Sinem
Mortazavi, Deniz
Korkunc, Seval Kubra
Kayalar, Ozgecan
Bayram, Hasan
Rahbarghazi, Reza
Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
title Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
title_full Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
title_fullStr Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
title_full_unstemmed Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
title_short Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
title_sort emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978512/
https://www.ncbi.nlm.nih.gov/pubmed/35379335
http://dx.doi.org/10.1186/s13287-022-02820-4
work_keys_str_mv AT rajabihadi emergingroleofexosomesinthepathologyofchronicobstructivepulmonarydiseasesdestructiveandtherapeuticproperties
AT konyalilarnur emergingroleofexosomesinthepathologyofchronicobstructivepulmonarydiseasesdestructiveandtherapeuticproperties
AT erkansinem emergingroleofexosomesinthepathologyofchronicobstructivepulmonarydiseasesdestructiveandtherapeuticproperties
AT mortazavideniz emergingroleofexosomesinthepathologyofchronicobstructivepulmonarydiseasesdestructiveandtherapeuticproperties
AT korkuncsevalkubra emergingroleofexosomesinthepathologyofchronicobstructivepulmonarydiseasesdestructiveandtherapeuticproperties
AT kayalarozgecan emergingroleofexosomesinthepathologyofchronicobstructivepulmonarydiseasesdestructiveandtherapeuticproperties
AT bayramhasan emergingroleofexosomesinthepathologyofchronicobstructivepulmonarydiseasesdestructiveandtherapeuticproperties
AT rahbarghazireza emergingroleofexosomesinthepathologyofchronicobstructivepulmonarydiseasesdestructiveandtherapeuticproperties

Ejemplares similares