Deubiquitination of FBP1 by USP7 blocks FBP1–DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors

Poly[ADP‐ribose] polymerase (PARP) inhibitors can block DNA single‐strand damage repair and subsequently increase double‐stranded breaks (DSBs) by reducing the activity of the PARP1 protease and by preventing the PARP1 protein from dissociating from chromatin. Tumors with the BRCA mutation are parti...

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Detalles Bibliográficos
Autores principales: Cheng, Xiang, Zhang, Bin, Guo, Feng, Wu, Heshui, Jin, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978517/
https://www.ncbi.nlm.nih.gov/pubmed/34854226
http://dx.doi.org/10.1002/1878-0261.13149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978517/
https://www.ncbi.nlm.nih.gov/pubmed/34854226
http://dx.doi.org/10.1002/1878-0261.13149

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